INTRODUCTION Phloroglucinol is an antioxidant compound with many positive effects on health. The purpose of this study was to determine the role of phloroglucinol in osteoclastogenesis via the RANKL/RANK signaling pathway and the activity of the transcription factor Nrf2. MATERIAL AND METHODS Analysis was performed in silico using the primary method of docking by the use of Hex 8.0 software a...

1. Mardini S, Salgado CJ, Kim Evans KF, Chen HC. Reconstruction of the esophagus and voice. Plast Reconstr Surg. 2010;126(2):471–85. 2. Rampazzo A, Gharb BB, Spanio di Spilimbergo S, Chung KP, Chen HC. Voice reconstruction with free ileocolon flap transfer: implications for the lower respiratory tract. Plast Reconstr Surg. 2011;127(5):1916–24. 3. Chen HC, Kuo HC, Chung KP, Chen SH, Tang YB, Su ...

Polycyclic aromatic hydrocarbons (PAH) are environmental contaminants that pose significant risk to health of fish. The International Workshop on Integrated Assessment of Contaminant Impacts on the North Sea (ICON) provided the framework to investigate biomarker responses as well as contaminant concentrations side by side in marine ecosystems. Concentrations of the main PAH metabolites 1-hydrox...

A total of 210 common minke whales (Balaenoptera acutorostrata) were sampled in five different areas the northeastern Atlantic during May-June 2000-04. Analysis forestomach contents revealed a relatively mixed diet at population level, whereas on an individual each whale had fed upon mainly one species. There significant differences composition between and some years. The importance krill Baren...

The analysis of results from Critical Assessment of Predicted Interactions (CAPRI), the first community-wide experiment devoted to protein docking, shows that all successful methods consist of multiple stages. The methods belong to three classes: global methods based on fast Fourier transforms (FFTs) or geometric matching, medium-range Monte Carlo methods, and the restraint-guided High Ambiguit...

This study reports temporal variations in the environmental conditions and the structure of fish assemblages observed in the vicinity of an offshore oil platform and the surrounding seafloor in the North Sea. Multi-seasonal sampling was conducted at a typical large steel jacketed facility, using mid-water fish traps at three different depths (i.e., 10, 50 & 100 m). Commercially important gadoid...

Crude oil spills are a worldwide ocean conservation threat. Fish are particularly vulnerable to the oiling of spawning habitats, and crude oil causes severe abnormalities in embryos and larvae. However, the underlying mechanisms for these developmental defects are not well understood. Here, we explore the transcriptional basis for four discrete crude oil injury phenotypes in the early life stag...