background and objectives: nasal polyposis is a diseases resulting from complex pathogenetic mechanisms. some studies showed that tgfβ1 had significant role in this pathogenesis. in this study, we investigated the roe of cytokines and mediators in polyp development. material and methods: in this case- control study, healthy nasal mucosal samples were obtained from 24 people undergoing septoplas...

Environmental pollution especially with heavy metals poses serious problem on product synthesis of medicinal plants cultivated in the field. Accordingly, the purpose of this study was to assess in vitro effects of cadmium as abiotic elicitor on phytoestrogens production by Psoralea corylifolia hairy roots. Transformed hairy roots were developed by genetic transformation using Agrobacterium rhiz...

We examined gene expression patterns in certain single and double pair-rule mutant embryos to determine which of the largely repressive pair-rule gene interactions are most likely to be direct and which interactions are probably indirect. From these studies we conclude that: (i) hairy+ and even-skipped (eve+) regulate the fushi tarazu (ftz) gene; (ii) eve+ and runt+ regulate the hairy gene; (ii...

hairy is a Drosophila pair-rule segmentation gene that functions genetically as a repressor. To isolate protein components of Hairy-mediated repression, we used a yeast interaction screen and identified a Hairy-interacting protein, the Drosophila homolog of the human C-terminal-binding protein (CtBP). Human CtBP is a cellular phosphoprotein that interacts with the C-terminus of the adenovirus E...

Sphenochoanal polyp is a rare form of choanal polyp. If unrecognised, they can be mistaken for an antrochoanal polyp. This will result in unnecessary exploration of the maxillary sinus, and a failure to remove the sphenoidal component of the sphenochoanal polyp. Adequate preoperative evaluation with computed tomography or magnetic resonance is mandatory to ascertain the correct diagnosis, and t...

Hairy cell leukemia is a rare disease comprising about 2% of lymphoid neoplasms.1 This neoplasm can be confused with other hematologic diseases. Therefore, a differential diagnosis must be performed between classic hairy cell leukemia, hairy cell leukemia variant, and splenic marginal zone lymphoma (SMZL).2 According to the World Health Organization (2008), hairy cell leukemia variant was class...

background: nasal inflammatory disorders such as chronic rhinosinusitis and nasal polyp are among the most prevalent complications with high socioeconomic costs. vascular endothelial growth factor (vegf) plays a key role in angiogenesis and cell proliferation. in the present study the effect of vegf on the development and prognosis of chronic rhinosinusitis and nasal polyp was investigated. met...

BACKGROUND Current measurement of the single longest dimension of a polyp is subjective and has variations among radiologists. Our purpose was to develop a computerized measurement of polyp volume in computed tomography colonography (CTC). METHODS We developed a 3D automated scheme for measuring polyp volume at CTC. Our scheme consisted of segmentation of colon wall to confine polyp segmentat...

Polyphosphate (polyP) is a ubiquitous biopolymer whose function and metabolism are incompletely understood. The polyphosphate kinase (PPK) of Acinetobacter sp. strain ADP1, an organism that accumulates large amounts of polyP, was purified to homogeneity and characterized. This enzyme, which adds the terminal phosphate from ATP to a growing chain of polyP, is a 79-kDa monomer. PPK is sensitive t...

Morbus Alzheimer neuropathology is characterized by an impaired energy homeostasis of brain tissue. We present an approach towards a potential therapy of Alzheimer disease based on the high-energy polymer inorganic polyphosphate (polyP), which physiologically occurs both in the extracellular and in the intracellular space. Rat pheochromocytoma (PC) 12 cells, as well as rat primary cortical neur...