Adoptive T-cell therapy with anti-CD19 chimeric antigen receptor (CAR)-expressing T cells is a new approach for treating advanced B-cell malignancies. To evaluate anti-CD19-CAR-transduced T cells in a murine model of adoptive T-cell therapy, we developed a CAR that specifically recognized murine CD19. We used T cells that were retrovirally transduced with this CAR to treat mice bearing a syngen...

We propose and study a one-dimensional traffic flow cellular automaton (CA) model of high speed vehicles with rapid acceleration as in Fukui-Ishibashi (FI) model and with stochastic delay as in Nagel-Schreckenberg (NS) model. This model is different from the NS model in that only the cars following the trail of the ahead car can be delayed. In other words, a car with spacing ahead longer than t...

A spatial process observed over a lattice or a set of irregular regions is usually modeled using a conditionally autoregressive (CAR) model. The neighborhoods within a CAR model are generally formed using only the inter-distances between the regions. To accommodate the effect of directions, a new class of spatial models is developed using different weights given to neighbors in different direct...

Traffic simulation is an often used tool in the study of traffic systems. A traffic simulation model consists of several sub-models; each handles one specific task in the simulation. These sub-models include, among others, car-following. This model controls the interactions with the preceding vehicle in the same lane. This paper compares and describes the car-following models used in the four t...

We apply the previously suggested accretion model for the behavior of the super-massive binary system η Carinae close to periastron passages. In that model it is assumed that for ∼ 10 week near periastron passages one star is accreting mass from the slow dense wind blown by the other star. We find that the secondary, the less massive star, accretes ∼ 2 × 10M⊙. This mass posses enough angular mo...

The aim of this paper is to contribute to describe the simultaneous choice of travel mode and 1 departure time by making use of a cross-nested logit structure that allows for the joint representation of 2 inter-alternative correlation along the both choice dimensions. Traditional multinomial logit model and 3 nested logit model are formulated respectively. The analysis uses the Revealed Prefere...

Drawing on a data set containing 371,082 observations on new and used cars from 2008, this study employs a hedonic model to estimate the determinants of prices in the primary and secondary car markets in Germany. We are specifi cally interested in identifying those vehicle attributes that are responsible for retaining the car’s value in the used car market. Beyond parameterizing the infl uence ...