Haloperidol has been shown to enhance attentional selectivity in conditioning procedures. For example, in latent inhibition (LI) it improves animals' ability to treat as irrelevant, stimuli that have previously been presented without consequence. The present study tested whether this finding would generalize to other procedures that present animals with weak predictors. We therefore used a trac...

a substantial amount of evidence has proposed an important role for cyclooxygenase-2 (cox-2) enzyme in brain diseases and affiliate disorders. the purpose of this research was studying the effects of cox-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and parkinson’s disease (pd). in this study, the effect of acute and sub-chronic oral administration ...

Ž . Magnetoencephalography MEG was used to determine the effect of neuroleptic challenge on brain responses in healthy subjects. In a double-blind, randomized, placebo-controlled, cross-over design study, the dopamine D2 Ž . receptor antagonist haloperidol 2 mg was given orally to 12 healthy volunteers. The middle-latency auditory evoked Ž . magnetic fields MAEF were recorded 3 h after administ...

This paper compares the metabolic changes associated with risperidone treatment in schizophrenia to those induced by haloperidol, as a representative typical neuroleptic. A group of 11 schizophrenic patients of recent onset underwent two [18F] fluoro-desoxi-glucose (FDG)-positron emission tomography (PET) scans at rest: the first one at the moment of the diagnosis, after a minimal treatment wit...

The combination of haloperidol and trihexyphenidyl is a dosage form to be used as antidyskinetic agent. Literature revealed that there is no single method for the simultaneous estimation of these drugs in tablet dosage form, which prompted us to develop a simple, rapid, accurate, economical and sensitive spectrophotometric method. The simultaneous estimation method is based on the principle of ...

The antipsychotic drug, haloperidol, elicits the expression of neurotensin and c-fos mRNA in the dorsal lateral region of the striatum and produces an acute cataleptic response in rodents that correlates with the motor side effects of haloperidol in humans. Mice harboring a targeted disruption of the RIIbeta subunit of protein kinase A have a profound deficit in cAMP-stimulated kinase activity ...

BACKGROUND The pharmacological management of violence in people with psychiatric disorders is under-researched. AIMS To compare interventions commonly used for controlling agitation or violence in people with serious psychiatric disorders. METHOD We randomised 200 people to receive intramuscular lorazepam (4 mg) or intramuscular haloperidol (10 mg) plus promethazine (25-50 mg mix). RESULT...

BACKGROUND Haloperidol is one of the most commonly used typical antipsychotics [2]. It has a powerful antipsychotic activity blocking mesolimbic postsynaptic dopamine receptors. Unwanted adverse effects accompany the use of haloperidol. Therefore alcohol abusers' attitudes towards haloperidol are ambiguous and often negative, which sometimes limits it's use in patients with addictive disorders ...

INTRODUCTION Haloperidol has been extensively used in various psychiatric conditions. It has also been reported to induce severe side effects. We aimed to evaluate whether haloperidol can influence host methylome, and if so what are the possible mechanisms for it in neuronal cells. Impact on host methylome and miRNAs can have wide spread alterations in gene expression, which might possibly help...

A major metabolic pathway of haloperidol is glucuronidation catalyzed by UDP-glucuronosyltransferase (UGT). In this study, we found that two glucuronides were formed by the incubation of haloperidol with human liver microsomes (HLM) and presumed that the major and minor metabolites (>10-fold difference) were O- and N-glucuronide, respectively. The haloperidol N-glucuronidation was catalyzed sol...