BACKGROUND Norepinephrine transporters (NETs) terminate the neuronal transmission of norepinephrine, which is released from noradrenergic neurons. To investigate the interaction with NET, the authors examined the effects of short- and long-term treatment with anesthetics on the activity and mRNA level of NET. METHODS To assay [3H]norepinephrine uptake, bovine adrenal medullary cells in cultur...

Molecule targeting therapy using somatostatin (SS) analogues has become a widely accepted modality to treat neuroendocrine tumors (NETs), particularly gastrointestinal (GI) and pancreatic endocrine tumors. On the other hand, little is known about the expression of somatostatin receptor (SSTR) subtypes in neuroendocrine carcinomas (NECs). We investigated the expression of SSTR subtypes (SSTR-1, ...

This paper presents a detailed economic modelling analysis of public finance in the transition towards carbon neutrality. It outlines results from Net-Zero Emission Ambition scenario, which reflects ambition to achieve net-zero dioxide emissions globally by mid-century, using broad and region-specific policy package that combines various instruments: pricing, removal fossil fuel support, regula...

The performance of Hopfield's neural net operating in synchronous and asynchronous modes is contrasted. Two interconnect matrices are considered: (1) the original Hopfield interconnect matrix; (2) the original Hopfield interconnect matrix with self-neural feedback. Specific attention is focused on techniques to maximize convergence rates and avoid steady-state oscillation. We identify two oscil...

We report here the activity of 96 cells in primate primary motor cortex (MI) during exertion of isometric forces at the hand in constant spatial directions, while the hand was at five to nine different spatial locations on a plane. The discharge of nearly all cells varied significantly with both hand location and the direction of isometric force before and during force-ramp generation as well a...