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BACKGROUND Hyaluronan is a critical component of extracellular matrix with several different roles. Besides the contribution to the tissue hydration, mechanical properties and correct architecture, hyaluronan plays important biological functions interacting with different molecules and receptors. SCOPE OF REVIEW The review addresses the control of hyaluronan synthesis highlighting the critica...
Lipoblastomas are pediatric neoplasms resulting from transformation of adipocytes. These benign tumors are typically composed of adipose cells in different stages of maturation within a variably myxoid matrix, and they contain clonal rearrangements of chromosome band 8q12. Because lipoblastomas resemble embryonic adipose tissue, characterization of their transforming mechanisms might reveal bio...
Human mesenchymal stem cells have been isolated from adult adipose tissue and lipoma that is a benign neoplasm of normal fat cells. The lipoma-derived LM6 cells exhibited a higher cumulative population doubling levels as compared with the adipose-derived AM3 cells. The expression profiles of both mRNAs and microRNAs (miRNAs) from AM3 and LM6 cells were found to exhibit considerable similarities...
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