Recent evidence indicates a new role for histone deacetylases (HDACs) in the activation of genes governing the host immune response. Virus, along with other pathogenic stimuli, triggers an antiviral defense mechanism through the induction of IFN, IFN-stimulated genes, and other proinflammatory cytokines. Many of these genes have been shown to be regulated by transcription factors of the IFN reg...

OBJECTIVE To determine and compare the reproducibility and speed of two methods of performing Bolton's tooth-size analysis. DESIGN Analysis of randomly selected clinical sample. SETTING Bristol Dental Hospital, University of Bristol, United Kingdom. MATERIALS AND METHODS Pre-treatment study casts of 150 patients were selected randomly from 1100 consecutively treated Caucasian orthodontic ...

Waldenström macroglobulinemia (WM) cells present with increased expression of microRNA-206 (miRNA-206) and reduced expression of miRNA-9*. Predicted miRNA-206- and -9*-targeted genes include histone deacetylases (HDACs) and histone acetyl transferases (HATs), indicating that these miRNAs may play a role in regulating histone acetylation. We were able to demonstrate that primary WM cells are cha...

The following problem was introduced by Marcin Krzywkowski as a generalization of a problem of Todd Ebert. After initially coordinating a strategy, n players each occupies a different vertex of a graph. Either blue or red hats are placed randomly and independently on their heads. Each player sees the colors of the hats of players in neighboring vertices and no other hats (and hence, in particul...

We review recent evidence that acetylation and deacetylation of cellular proteins, including transcription factors and nuclear cofactors, may be involved in the regulation of muscle mass. The level of protein acetylation is balanced by histone acetyltransferases (HATs) and histone deacetylases (HDACs) and studies suggest that this balance is perturbed in muscle wasting. Hyperacetylation of tran...

The existence of distinct high- and low-affinity transport systems (HATS and LATS) is well established for major nutrient ions. However, influx mediated by these systems is usually estimated using uniformly simple tracer protocols. Two (42)K radiotracer methods to measure potassium influxes in the HATS and LATS ranges in intact barley (Hordeum vulgare L.) roots are compared here: a direct influ...

In order to take head movement into account in objective evaluation of perceived spatial impression (including source direction), a suitable binaural capture device is required. A signal capture system was suggested that consisted of a head-sized sphere containing multiple pairs of microphones which, in comparison to a rotating head and torso simulator (HATS), has the potential for improved mea...

Acetylation of histones plays an important role in regulating transcription. Histone acetylation is mediated partly by the recruitment of specific histone acetyltransferases (HATs) and deacetylases (HDACs) to genomic loci by transcription factors, resulting in modulation of gene expression. Although several specific interactions between transcription factors and HATs and HDACs have been elabora...

Histone acetyltransferases (HATs) play vital functions in the tumorigenesis of many solid organ malignancies. We previously screened a human HATs cDNA library and identified Tat-interactive protein-60KDa (TIP60) as a candidate critical HATs in the origination of lung cancer. In this study, our data suggested that overexpression of TIP60 inhibited the cell viability of A549 and H1299 cells since...