Manuscript received and accepted: 5 July and 4 October 2008 Editor, hepatitis B virus (HBV) infection is an important viral infection. Chronic HBV infection can result in a very serious complication, hepatoma. HBV serology is a basic screening test in laboratory medicine at present. Of several serological parameters, HBs Ag is the suggested parameter for HBV screening. Since this test is easily...

background chronic hepatitis b is one of the most common causes of cirrhosis and hepatocellular toxicity in many countries, including iran. cytotoxic t lymphocyte (ctl) and natural killer (nk) cells are the two of main cell populations considered as cytotoxic cells. one of the distinct pathways ctl and nk cells exert cytotoxicity is perforin/granzyme. after the cytotoxic cell/target cell juncti...

BACKGROUND The risk of infection with transfusion-transmitted viruses, such as Hepatitis B virus (HBV), has been reduced markedly. However, a zero-risk blood supply remains a popular goal. Anti-hepatitis B core antigen (anti-HBc) is considered to be an effective marker for occult HBV infection, and it has served a significant role in improving blood safety. The purpose of this study was to dete...

proteinase K and was then incubated for 4 hrs at 55•Ž . After approximately 30 mg of nail clippings in a 1.5 ml microtest tube were rinsed once with 1.0 N NaOH and twice with distilled water, the nails were mixed with 300ƒÊ1 of 4 M guanidine thiocyanate, 0.5% (w/v) sodium N-lauroyl salcosinate, 25 mM sodium citrate, and 0.1 mM 2-mercaptoethanol [7], and were incubated at room temperature over n...

Hepatitis B vaccination is safe and effective, although breakthrough infection occasionally occurs in those who receive the vaccine and hepatitis B immunoglobulin (HBIg) prophylaxis. Sequence variation in their antigenic regions is one of the most powerful strategies that are used by viruses to escape recognition by B and T cell-mediated immune responses. The aim of this study was to explore th...

hepatitis b vaccination is safe and effective, although breakthrough infection occasionally occurs in those who receive the vaccine and hepatitis b immunoglobulin (hbig) prophylaxis. sequence variation in their antigenic regions is one of the most powerful strategies that are used by viruses to escape recognition by b and t cell-mediated immune responses. the aim of this study was to explore th...

hepatitis b is the most common cause of acute and chronic viral hepatitis in iran. it is the etiology of 70% of end-stage liver disease and hepatocellular carcinoma in the country. before the universal neonatal vaccination in iran (1992), the contact rate with hbv was about 30% and the hbs ag+ rate was about 3%. in 2009 the contact rate has declined to 18% and hbsag+ rate decreased to 2%. the e...