Platelet aggregation indicating antigen-antibody complex formation was observed when hepatitis B surface (HBs) antigen and antibody were mixed. Platelet aggregation titers were determined for serum specimens found positive by radioimmunoassay for either HBs antigen or HBs antibody. From these determinations, incidence of HBs antigen-antibody complexes was found to be higher in HBs antigen seraa...

HEPAXPERT is a knowledge-based system that interprets the results of routine serologic tests for infection with hepatitis A and B viruses. The following tests are included: hepatitis A virus anti-bodies (anti-HAV), IgM antibodies to the hepatitis A virus (IgM anti-HAV), hepatitis A virus (HAV in stool, hepatitis B surface antigen (HBsAg) and antibodies (qualitative anti-HBs, quantitative anti-H...

In the recent issue of Middle East Journal of Digestive Diseases, we read with great interest the article by Bahari et al.1, “Significance of response to hepatitits B vaccine in subjects with isolated antibody to hepatitis B core antigen”. We wanted to specify some important matters related to the article. Initially, definition of occult hepatitis B virus infection is the existence of hepatitis...

The aim of this study was to compare the sensitivity and specificity of morphine-augmented hepatobiliary scintigraphy (MA-HBS) with that of conventional hepatobiliary scintigraphy (C-HBS) for acute cholecystitis. The results of most MA-HBS studies cannot be compared with C-HBS estimates, since articles describing C-HBS often include non-candidates for MA-HBS. However, using meta-analytic techni...

H epatitis B virus (HBV), hepatitis C virus (HCV), and HIV infections represent a global public health problem. Transmission of these viruses occurs via blood and blood products transfusion and by sexual contact (1). The infections caused by the three viruses are not curable even with the latest available treatments. Effective vaccine is available only for HBV. In Libya, Zaied et al. (2), repor...

Sickle hemoglobin (Fe(II)HbS) reconstituted with nickel(II)protoporphyrin IX yields an artificial hemoglobin (Ni(II)HbS), the first heme-substituted hemoglobin shown to mimic the polymerization of deoxyHbS. Unlike Fe(II)HbS, Ni(II)HbS does not bind oxygen and therefore polymerizes under aerobic conditions. While the polymer solubility coefficient (Csat) for Ni(II)HbS is elevated about 2 g/100 m...

background: hepatitis a virus (hav) is a single strand and non-enveloped rna virus. it is usually transmitted by the fe­cal-oral and the blood transfusion routes and causes the hepatitis a disease. clinically, the hepatitis a is usually mild, par­ticularly in children, in whom it is frequently subclinical. the disease is more serious and prolonged in adults. the objective of this study was to f...

BACKGROUND Blood and plasma donor screening for hepatitis B virus (HBV) DNA, HBV surface antigen (HBsAg), and antibodies to surface (anti-HBs) and core (anti-HBc) antigens allows identification of individuals who acquired HBV despite previous HBV vaccination. METHODS Of 14 HBV acute infection donor panels (HBV-DNA-positive/anti-HBc-negative), 6 donors were previously vaccinated (anti-HBs+). W...

The genetic immunization of rodents with a plasmid coding for a Plasmodium chabaudi merozoite surface protein 1 (C terminus)-hepatitis B virus surface fusion protein (pPcMSP1(19)-HBs) provided protection of mice against subsequent lethal challenge with P. chabaudi chabaudi PC1-infected red blood cells. The percentage of survivor mice was higher in DNA-immunized mice than in animals immunized wi...

background the impact of hepatitis b virus (hbv) vaccination campaigns on hbv epidemiology needs to be evaluated, in order to assess the long-term immunity offered by vaccines against hbv. objectives to evaluate the current status of anti-hbv vaccine coverage among healthcare workers (hcws) in southern italy, and to determine the long-term persistence of antibodies to hepatitis b surface antige...