AIM To investigate the association between smoking habits and surgical outcomes in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) (B-HCC) and hepatitis C virus (HCV)-related HCC (C-HCC) and clarify the clinicopathological features associated with smoking status in B-HCC and C-HCC patients. METHODS We retrospectively examined the cases of the 341 consecutive patients with viral...

Currently, there is no reliable biomarker for use in diagnosing alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC). Such a biomarker would aid in making an early diagnosis of AFP-negative HCC, ensuring the timely initiation of treatment. This study examined AFP-L3 and Golgi protein 73 (GP73) as candidate biomarkers for AFP-negative HCC. The affinity adsorption method and enzyme-lin...

Hepatocellular carcinoma (HCC) is one of the most common cancers in world. Alpha-fetoprotein (AFP) important diagnostic markers for HCC. However, over 30% HCC patients are negative AFP (< 20 ng/mL), emphasizing great need new biomarkers early diagnosis. A cohort 100 AFP-negative early-stage and controls consisting a discovery group two validation groups was constructed. UPLC-MS/MS performed on ...

Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality. At present, diagnostic methods such as imaging observation, serum testing tissue biopsy, well treatment surgical resection, radiotherapy, chemotherapy have certain limitations in clinical interventions for HCC due to the complex pathogenesis drug resistance of liver cancer, which seriously affect survival pro...

Successive current trials using immune response checkpoint blockade, the systemic therapy for progressive hepatocellular carcinoma (HCC) has shifted dramatically towards targeting tumor microenvironment (TME). Locoregional therapies (LRTs) like radiofrequency ablation (RFA)/rhizotomy, trans-arterial chemoembolization (TACE) and surgical resection in initial stages are critical. LRTs perform cru...

Although several therapeutic options are available for hepatocellular carcinoma (HCC), the outcome is still very poor. One reason is the complexity of signal transduction in the pathogenesis of HCC. The aim of this study was to identify new HCC-related genes and to investigate the functions of these genes in the pathogenesis and progression of HCC. Whole genomes of 15 surgically resected HCC sp...

N-myc downstream regulated gene 1 (NDRG1)/Cap43 is a 43 kDa protein that is widely distributed in the body. Its expression is regulated by nickel, cobalt, hypoxic condition and others; it is reported to be weaker in tumors than normal tissues; and NDRG1/Cap43 is considered to act suppressively to tumor metastasis. This current study immunohistochemically examined NDRG1/Cap43 expression in hepat...

BACKGROUND The value of hepatic resection (HR) for huge hepatocellular carcinomas (HCC) (≥ 10 cm in diameter) remains controversial. The aim of this study is to evaluate the efficacy of hepatic resection (HR) for patients with huge HCC. METHODS A total of 739 patients with huge HCC (≥ 10 cm in diameter) (huge HCC group, n = 244) or small HCC (< 10 cm in diameter) (small HCC group, n = 495) wh...

Abstract Multicentric fibrolamellar hepatocellular carcinoma has not been reported yet in the world as of our knowledge. A Medline search for term “multicentric HCC” did return any results. To knowledge, this is first case report multi-centric (HCC). We present a 22-year-old male patient who had complaints epigastric pain 1 month. His general physical examinations were normal. Computed tomograp...