Narcolepsy type 1 is associated with loss of orexin neurons, sleep-wake derangements, cataplexy, and a wide spectrum of alterations in other physiological functions, including energy balance, cardiovascular, and respiratory control. It is unclear which narcolepsy signs are directly related to the lack of orexin neurons or are instead modulated by dysfunction of other neurotransmitter systems ph...

BACKGROUND High-dose chemotherapy (HDC) has been widely utilized in high-risk breast cancer, but it may induce cardiac toxicity. Cardiac dysfunction may become evident weeks or months after HDC and, to date, no early markers of myocardial injury that are able to predict late ventricular impairment are available. We investigated the role of plasma troponin I (TnI) in this setting. PATIENTS AND...

High-dose cyclophosphamide (HDC) is a chemotherapy treatment designed to eradicate autoreative B- and T-cells responsible for lymphocyte-mediated autoimmune illness while sparing the pluripotent blood stem cell of any ill effects. Multiple sclerosis (MS) is the most common inflammatory and demyelinating immune-mediated disorder of the central nervous system in young adults. Patients with modera...

Histamine in food can cause intolerance reactions in consumers. Lactobacillus parabuchneri (L. parabuchneri) is one of the major causes of elevated histamine levels in cheese. Despite its significant economic impact and negative influence on human health, no genomic study has been published so far. We sequenced and analyzed 18 L. parabuchneri strains of which 12 were histamine positive and 6 we...

The purpose of this research is to overcome the weaknesses intellectual capital (IC) estimation models, constructing and empirically verifying a new model that has same strengths as value-added coefficient (VAIC) but not its weaknesses. To better outline our analysis with respect many meanings can be evoked by term IC in literature, we also define term: “hidden capital” (HDC) balance sheet. Fir...

we review and comment on the data from ran-domized studies so far reported and try to indicate what could be next in this story. We also suggest what may be the attitude we should take in our everyday clinical practice. Operable, high-risk breast cancer (adjuvant therapy) In the early 1990s phase II studies from several centers and the European and American registries showed a 60-65% disease-fr...

The ability of histamine to stimulate gastric acid secretion was recognized over 75 years ago by Popielski [1]. The central importance of this action in the physiological regulation of acid secretion was established with the development of histamine H2 receptor antagonists by Black and colleagues in the early 1970s [2]. There has, however, been intense debate about the precise mechanisms of act...

Each year in the USA, 180,000 new cases of breast cancer are diagnosed and about 44,000 women die of the disease. Current primary treatment consists of adjuvant chemotherapy and hormone therapy, and statistics show that combination chemotherapy favorably influences the outcomes in both node-negative and node-positive primary disease. However, a significant number of breast cancer patients succu...

Data from rat models for alcohol preference and histidine decarboxylase knockout (HDC KO) mice suggest that brain histamine regulates alcohol-related behaviors. Histamine levels are higher in alcoholpreferring than alcohol non-preferring rat brains, and expression of histamine H3 receptor is different in key areas for addictive behavior. Histamine H3 receptor inverse agonists decrease alcohol r...

The course and outcome of infection with mycobacteria are determined by a complex interplay between the immune system of the host and the survival mechanisms developed by the bacilli. Recent data suggest a regulatory role of histamine not only in the innate but also in the adaptive immune response. We used a model of pulmonary Mycobacterium tuberculosis infection in histamine-deficient mice lac...