BACKGROUND Patients with head and neck cancer are at high risk for second primary malignancies. Human papillomavirus (HPV)-driven tumors are generally high-grade oropharyngeal cancers. We analyzed the incidence of second primary malignancy of the head and neck in patients with primary squamous cell carcinoma (SCC) of the head and neck and temporal trends in the HPV era. METHODS The Surveillan...

Human papillomavirus (HPV) has changed the face of head and neck cancer over the past 2 decades. No longer is this solely a disease of older patients with a history of heavy tobacco and alcohol use. Patients with HPV-related head and neck cancers tend to be younger, healthier, and have an improved prognosis, compared with those with HPV-negative tumors. As more patients are diagnosed with HPV-r...

We presented 9 recurrent head and neck carcinoma patients. Priorly all of them had received radiochemotherapy. We used cetuximab and irradiation concomitantly. Overall survival analysis of the patients was performed using the Kaplan-Meier method on SPSS version 15.0. Based on this calculation, mean follow-up duration is 12.8 months. Mean survival time is 19.8 months and annual mean survival rat...

Delivery of therapeutic radiation in multiple sessions, or fractions, has been practiced since the discovery of radiation’s potential to cure malignancies. Initially, this was done out of practical necessity: Radiation was delivered at a low dose rate, and the treatment sessions had to be repeated to obtain the desired effect. Technologic improvements eventually allowed for treatments in one se...

1 Gate-UMR 58234, University of Lyon, Lyon, France, 2 Leon Berard Cancer Centre, Lyon, France, 3 Institut Régional de Cancérologie de Montpellier, Montpellier, France, 4 Centre Oscar Lambret, Lille, France, 5 Clinique Pasteur, Toulouse, France, 6 Institut Sainte Catherine, Avignon, France, 7 Centre René Gauducheau, Saint Herblain, France, 8 Institut Claudius Regaud, Toulouse, France, 9 Institut...