BACKGROUND Although increasingly accepted in treatment of the N0 neck, use of selective neck dissection in patients with node-positive squamous cell carcinoma of the head and neck remains controversial. OBJECTIVE To determine the oncologic efficacy of selective node dissection in patients with node-positive squamous carcinoma of the head and neck. SETTING Three tertiary care academic/Vetera...

Targeted agents have emerged as novel drugs in the oncology field based on our understanding of the biology of individual malignancies, and have had a promising impact in several tumors. Squamous cell carcinoma of the head and neck (SCCHN) is a common disease with little progress made in survival over the past few decades. SCCHN is characterized by overexpression of the epidermal growth factor ...

Sinonasal carcinomas are rare and account for 3% of all malignant tumours of head and neck. Squamous cell carcinoma is the commonest histological variant. We present a case of sinonasal squamous cell carcinoma in a 52-years-male and another rare case of intestinal type sinonasal adenocarcinoma in 50-years-male.

September 01, 2008 About 500,000 head and neck carcinomas are diagnosed worldwide annually. This accounts for approximately 8% of all newly diagnosed cases of cancer, ranking head and neck carcinoma the sixth most common.[1] In the United States, 47,560 new head and neck carcinomas are expected to be diagnosed in 2008,[2] and this disease accounts for 5% of all newly diagnosed cases of cancer. ...

We have previously shown that detection of autologous antibody activity to squamous cell carcinoma of the head and neck may be augmented by dissociation of immune complexes. Western blot analysis with autologous antibody has identified a 60 kDa squamous cell carcinoma of the head and neck-associated antigen in spent media and immune complex-dissociated serum ultrafiltrate not recognized by norm...

This review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV-positive HNSCC and the genome-wide changes assoc...

Adenoid squamous cell carcinoma (ASCC) is an uncommon but well recognized variant of squamous cell carcinoma. It has been reported to originate in the sun exposed skin of the head and neck region. Although rare, there are cases in records which have reported within the oral cavity and nasopharynx. Histologically the lesion shows areas of conventional squamous cell carcinoma along with atypical ...

Sessions covered metastatic breast cancer, cachexia in non-small-cell lung cancer, recurrent and/or metastatic head and neck squamous-cell carcinoma, and melanoma.

4. Lewis JE, Olsen KD, Sebo TJ. Spindle cell carcinoma of the larynx: Review of 26 cases including DNA contentandimmunohistochemistry Hum Pathol 1997; 28: 664-673. 5. Lane N. Pseudosarcoma (polypoid sarcoma-like masses) associated with squamous cell carcinoma of the mouth, tauces and larynx. Report ot10 cases. Cancer 1957; 10:19-41. 6. Ackerman LV. Verrucous carcinoma ofthe oral cavity Surgery ...

Despite advances in surgery, radiotherapy, and chemotherapy, survival of patients with squamous cell carcinoma of the head and neck has not significantly improved over the past 30 years. Locally recurrent or refractory disease is particularly difficult to treat. Repeat surgical resection and/or radiotherapy are often not possible, and long-term results for salvage chemotherapy are poor. Recent ...