Simultaneous cardiac and renal involvement is associated with a particularly poor prognosis in patients with AL amyloidosis (AL-A). We report the first case of a successful long-term outcome of combined heart and kidney transplantation not followed by autologous stem cell transplantation in a patient with systemic AL-A. The recipient was a 46-year-old man with end-stage renal failure associated...

Cardiac allograft vasculopathy is the leading cause of death after the first year of heart transplantation. The optimal treatment for unprotected left main coronary artery disease in orthotopic heart transplantation (OHT) patients is unknown. Two OHT patients with left main disease following heart transplantation underwent percutaneous coronary intervention (PCI). Technical success was achieved...

A case control study was performed to determine whether previous implantable cardioverter-defibrillator(ICD)insertion adversely affects outcome after heart transplantation. Six male heart transplant recipients who had undergone lCD insertion 12 ±5 months before heart transplantation were compared to a cohort ofsix heart transplant recipients who were matched according to age, preoperative statu...

BACKGROUND Heterotopic thoracic heart transplantation may be an alternative to the established heterotopic abdominal or orthotopic cardiac xenotransplantation model as it combines the safety of heterotopic transplantation with the benefit of a working heart model. METHODS In a first series of two animals, we tested the surgical feasibility of this procedure with non-transgenic pig hearts tran...

Heart transplantation in a recipient with giant left atrium is rare. To correct the mismatch between and donor at level of atrium, plication has been proposed. We report case which was not feasible owing to significant calcification atrial wall tight pericardial adhesions resulting from two previous sternotomies. Creating pulmonary venous confluence allows orthotopic heart any size conformation...

Ischemia reperfusion (I/R) injury is an unavoidable event occurring during heart transplantation, leading to graft failures and lower long-term survival rate of the recipient. Several studies have demonstrated that microRNAs (miRNAs) are vital regulators of signalling pathways involved in I/R injury. The present study aims to quantify the altered expression levels of miRNA and mRNA upon I/R inj...

Background—The purported advantage of ABO-incompatible (ABO-I) listing is to reduce wait times and wait-list mortality among infants awaiting heart transplantation. We sought to describe recent trends in ABO-I listing for US infants and to determine the impact of ABO-I listing on wait times and wait-list mortality. Methods and Results—In this multicenter retrospective cohort study using Organ P...

BACKGROUND The presence of cardiac reinnervation in humans after cardiac transplantation has been widely debated, based on the application of differing methods for the assessment of neuronal function. Some of these techniques have been rather indirect; consequently, the time course and extent of cardiac reinnervation remains uncertain. METHODS AND RESULTS To test for the presence of cardiac r...