BACKGROUND & OBJECTIVES Studies of interaction between viruses and mitochondria have shown that viruses can affect the mitochondria. Also linkage between human diseases and mitochondrial dysfunction has been revealed. We studied the effect of measles virus (MV) on cell respiration in MV infected Hela cells to see any possible changes in mitochondrial respiration. METHODS Total cell respiratio...

Twelve phosphonopropionates derived from 2-hydroxy-3-imidazo[1,2- a ]pyridin-3- yl -2-phosphonopropionic acid (3-IPEHPC) were synthesized and evaluated for their activity as inhibitors of protein geranylgeranylation. The nature the substituent in C6 position imidazo[1,2- ]pyridine ring was responsible compound's against Rab geranylgeranyl transferase (RGGT). most active disrupted Rab11A prenyla...

objective: verotoxin is a member of shiga toxin family. this family contains ab protein toxins with an enzymatic (a) and a binding (b) compartment. cells that have receptor (gb3) are sensitive to cytotoxic effects of toxin. it has been shown that various tumor cells have gb3 receptor and are selectively sensitive to apoptotic effect of verotoxin. studies on tumor cell lines and laboratory anima...

objective: today, special attention is paid to the use of zirconium dioxide nanoparticle (nano-zro2), a neutral bioceramic metal, particularly for drug and gene delivery in medicine. however, there are some reports implying that use of nano-zro2 is associated with cytotoxic effects like inhibiting the cell proliferation, dna damage and apoptosis. in the present study, we examined whether nano-z...

This study aimed to investigate the effect of fullerenol combined with cisplatin on the proliferation of cervical cancer HeLa cells in order to provide new ideas and laboratory theoretical basis for the clinical treatment of cervical cancer. Cervical cancer cell line HeLa cells in vitro were treated with different concentrations of fullerenol, different concentrations of cisplatin, and differen...

quinazolinone backbone is present in a large number of bioactive substances. since remarkable cytotoxic activity is associated with some 4(3h)-quinazolinones, in this study some 4(3h)-quinazolinone were synthesized and screened against hela cells. the synthesis was performed via reaction of anthranilic acid with dicarboxylic anhydrides to produce carboxylic acids derivatives. the products were ...

Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a hardly curable disease with high relapse rate. 20 analogs were synthesized based on the structures of two kinds fungi-derived polyenylpyrrole products (rumbrin (1) and auxarconjugatin-B (2)) to suppress growth T-ALL-derived cell line CCRF-CEM tested for growth-inhibiting activity. The octatetraenylpyrrole analog gave an IC50 0.27 μM in c...

The current study examined the genotoxic effect of biosynthetic zinc oxide nanoparticles ZnONPs using Vitex agnus-castus plant, which contains effective compounds that inhibit growth pure cancer cells. phenotypic and structural characteristics biosynthesized were detected scanning electron microscopy (SEM). Most dense spherical with sizes ranging from (20-61) nanometers, on cervical cell line H...