The authors study the short-time dynamics of helix-forming polypeptide chains using an all-atom representation of the molecules and an implicit solvation model to approximate the interaction with the surrounding solvent. The results confirm earlier observations that the helix-coil transition in proteins can be described by a set of critical exponents. The high statistics of the simulations allo...

Protein α-helical coiled coil structures are known to induce antibodies able to block critical functions in different pathogens. In a previous study, a total of 50 proteins of Plasmodium vivax erythrocytic asexual stages containing α-helical coiled coil structural motifs were identified in silico, and the corresponding peptides were chemically synthesized. A total of 43 peptides were recognized...

Tooth enamel, the hardest material in the human body, is formed within a self-assembled matrix consisting mostly of amelogenin proteins. Here we have determined the complete mouse amelogenin structure under physiological conditions and defined interactions between individual domains. NMR spectroscopy revealed four major amelogenin structural motifs, including an N-terminal assembly of four α-he...

Simple helix-coil transition theories have been indispensable tools in the analysis of data reporting on the reversible folding of α-helical polypeptides. They provide a transferable means to not only characterize different systems but to also compare different techniques, viz., experimental probes monitoring helix-coil transitions in vitro or biomolecular force fields in silico. This article a...

It is known that different amino acid residues have effects on the thermodynamic stability of an alpha-helix. The underlying mechanism for the thermodynamic helical propensity is not well understood. The major accepted hypothesis is the difference in the side-chain configurational entropy loss upon helix formation. However, the changes in the side-chain configurational entropy explain only part...

In this study, the researchers have proposed an alternative technique for designing asymmetric 4 coil-resonance coupling module based on series-to-parallel topology at 27 MHz industrial scientific medical (ISM) band to avoid tissue damage, constant monitoring of in-stent restenosis coronary artery. This design consisted 2 components, i.e., external part that included 3 planar coils were placed ...

An adjoint method to calculate the gradient of island width in stellarators is presented and applied a set magnetic field configurations. The underlying calculation that Cary & Hanson (1991) (with minor modification), requires residue centre be small. Therefore, calculated addition. Both calculations are verified using an analytical configuration introduced Reiman Greenside (1986). also shape N...

The need to understand the structure of magnetic fluctuations in H-1NF heliac [S. Hamberger et al., Fusion Technol. 17, 123 (1990)] plasmas has motivated the installation of a sixteen former, tri-axis helical magnetic probe Mirnov array (HMA). The new array complements two existing poloidal Mirnov arrays by providing polarisation information, higher frequency response, and improved toroidal res...

The force-free helical reactor (FFHR) is a helical-type fusion reactor whose design is being studied at the National Institute for Fusion Science. The FFHR will use three sets of superconducting coils to confine the plasma. It is not a fusion plasma experimental device, and the magnetic field configuration will be optimized for burning plasma. This paper introduces a conceptual design for a dc ...

Molecular structures such as conformation and orientation are crucial in determining the activity of peptides immobilized to solid supports. In this study, sum frequency generation (SFG) vibrational spectroscopy was applied to investigate such structures of peptides immobilized on self-assembled monolayers (SAMs). Here cysteine-modified antimicrobial peptide cecropin P1 (CP1) was chemically imm...