Splenic infarction is a clinical entity seldom encountered. The most frequent causes of splenic infarction include thromboembolic phenomena, hematologic malignant neoplasms, and vasculitides. We describe a patient who sustained splenic infarction secondary to diabetes-induced, small-vessel atherosclerotic disease.

• Microbiota includes commensal and pathogenic microorganisms colonizing human body. Dysbiosis may favour the development of oncologic benign hematologic diseases. Chemotherapy immunesuppression worsen dysbiosis infections. Antibiotic prophylaxis/therapy be detrimental for microbiome composition. Novel target therapies induce possibly impacting on outcome. Growing evidence suggests impact alter...

background: sulfur mustard was the most widely applied chemical warfare agent by the iraqi army in iran–iraq war (1983-1988). considering the role of sulfur mustard toxicity in hematopoietic neoplasms and also new role of jak2 mutation in these neoplasms, we assessed this mutation and delayed hematologic complications in veterans exposed to sulfur mustard. methods: this case control study was p...

background: for its toxicity, benzene exposure is one of the main health concerns for high risk occupations like gasoline station workers. however, there is little knowledge about the effect of benzene metabolites on hematological parameters. objective: to evaluate the correlation between the urinary level of trans, trans-muconic acid (t, t-ma), a benzene metabolite, and some hematological para...

Prior to diagnosis, patients with haematological cancers often have multiple primary care consultations, resulting in Diagnostic Delay. They are less likely to be referred urgently to hospital and often present as emergencies. Howell et al. [1] examined patient perspectives of time to help-seeking and diagnosis, as well as associated symptoms and experiences using the following method; The UK’s...

Oncogenes are activated forms of cellular genes involved in normal cell growth and development. Some oncogenes play a role in human malignancies. In hematologic malignancies, researchers have identified many transcription factors as oncogenes based on one of the following criteria: their association with transforming retroviruses in animals, their translocation into either the immunoglobulin or...

A phase I dose-escalation study of MSC1992371A, an oral aurora kinase inhibitor, was carried out in patients with hematologic malignancies. Patients received escalating doses either on days 1-3 and 8-10 (n=36) or on days 1-6 (n=39) of a 21-day cycle. The maximum tolerated doses were 37 and 28 mg/m(2)/day, respectively. Dose-limiting toxicities included severe neutropenia with infection and seps...

The clinical, hematologic, and immunologic findings of a syndrome of agranulocytosis, hypogammaglobulinemia, and thymoma are described. Neutrophil agranulocytosis predisposing to severe infectious disease resulted from a deficiency of mature cells in bone marrow. Autologous and heterologous stem cell growth in vitro was inhibited by the patient's serum. Immunoglobulin deficiency was secondary t...

background a fungal infection represents a growing problem in children with hematologic malignancies,during chemotherapy induced neutropenia.fungal colonization is considered a major riskfactor for subsequent fungal infections. the aim of this retrospective study was to evaluate prevalence of fungal infection among children admitted to hospital between 2005 and 2010 in tehran, iran. materials a...

conclusions with regards to the high incidence of gasterointestinal parasitic diseases and also because of asymptomatic cases of giardiasis, we recommend evaluation of pediatric patients with malignant lymphohematopoitic disease by at least two different diagnostic methods and three rounds of stool examination in order to prevent possible life threatening outcomes. coproparasitoscopic study for...