The SCA6 mutation, a small expansion of a CAG repeat in a calcium channel gene CACNA1A, was identified in three pedigrees. Point mutations in other parts of the gene CACNA1A were excluded and new clinical features of SCA6 reported--namely, central positional nystagmus and episodic ataxia responsive to acetazolamide. The three allelic disorders, episodic ataxia type 2, familial hemiplegic migrai...

Case presentation: 1: Female patient, hospitalized at 15 years for investigation of hemiplegia and right hemiparesis accompanied by vomiting fever without local history signs. At 16 similar condition, with unchanged resonance complete remission in two weeks. Genetic was performed hemiplegic migraine, identification heterozygosis mutation the ATP1A2 gene (c.2563G>A). 2: An 11-year-old female pat...

PURPOSE Studies of the visual evoked potentials (VEP) in migraine have yielded contradictory results. Several investigators suggested that VEP may be helpful test in diagnosis of a child with headache. The aim of our study was to compare interictal pattern-reversal visual evoked potentials (PR-VEP) in children and adolescents with migraine and tension-type headaches and to evaluate VEP paramete...

Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial hemiplegic migraine type 1: FHM1) is caused by mutations in Ca(V)2.1 (P/Q-type) Ca(2+) channels. Knockin mice carrying a FHM1 mutation show increased neuronal P/Q-type current and facilitation of induction and propagation of cortical spreading depression (CSD), the phenomenon that underlies migraine aura an...

Migraine is a common episodic headache disorder. A comprenhensive headache treatment plan includes acute attack treatment to releive pain and impairment and long-term preventive therapy to reduce attack frequency, severity and duration. Circumstances that might warrant preventive treatment include very frequent and severe migraine that interferes with the patient's daily routine, failure to acu...

Migraine, both with (MA) and without aura (MOA), is well recognized as being recurrent in families, although the exact mode of inheritance is unclear. There are abundant examples of migraine families whose pattern of affliction suggests a simple “monogenic” or mendelian genetic disorder (1). However, the vast majority of “sporadic” migraineurs cannot be consistently categorized by segregation a...

Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial hemiplegic migraine type 2: FHM2) is caused by loss-of-function mutations in α2 Na(+),K(+) ATPase (α2 NKA), an isoform almost exclusively expressed in astrocytes in adult brain. Cortical spreading depression (CSD), the phenomenon that underlies migraine aura and activates migraine headache mechanisms, is fa...

Migraine is a paroxysmal neurologic disorder affecting up to 12% of males and 24% of females in the general population. Two main types are distinguished: migraine without aura (MWOA) and migraine with aura (MWA), in which headache is preceded by transient focal neurologic symptoms (usually visual). Attacks of only MWOA are reported by about 70% of patients with migraine, while at least occasion...

BACKGROUND Since the mid-19th century, epistaxis and migraine have been occasionally associated with each other. Nevertheless, we found only two cases in the contemporary medical literature. Sporadic hemiplegic migraine is a subtype of migraine with reversible motor deficits, without similar episodes in relatives. CASE We describe a 47-year-old male with a history of migraine with a scintilla...