in an attempt to determine the clinical value of frnctosamine assay for monitoring type ii diabetic patients, correlation of frnctosamine with glycosylated hemoglobin was studied. 100 patients with type ii diabetes mcllitus were compared with 100 normal subjects. fasting blood glucose, glycosylated hemoglobin, albumin and frnctosamine were measured in alt subjects. in the diabetic patients, a s...

Haemophilus ducreyi, the etiological agent of chancroid, has a strict requirement for heme, which it acquires from its only natural host, humans. Previously, we showed that a vaccine preparation containing the native hemoglobin receptor HgbA purified from H. ducreyi class I strain 35000HP (nHgbAI) and administered with Freund's adjuvant provided complete protection against a homologous challeng...

Accepted October 13, 1983 It is well known that glycosylated hemo globin (HbA1) increases in the blood of diabetic patients. However, only few studies have been reported on the changes in the values of HbA1 in mice and rats. The degree of increase in HbA1 levels was not correlated with the severity of hyperglycemia, duration of diabetes, age of the mouse, or body weight in C57BL/KsJ mice (1). I...

BACKGROUND China has the world's highest diabetes prevalence, which along with hypertension and inflammation continues to grow particularly among children. Little is known about the strength of the association of these cardiometabolic risk factors between parents and their children; thus, the potential of household-based strategies to reduce risk is unknown. OBJECTIVES The objective of the st...

For therapeutic studies, predictive validity of animal models - arguably the most important feature of animal models in terms of human relevance - can be calculated retrospectively by obtaining data on treatment efficacy from human and animal trials. Using rosiglitazone as a case study, we aim to determine the predictive validity of animal models of diabetes, by analysing which models perform m...

The synthesis of ‘yand /9-globin chains was investigated in erythroid cultures from first and second trimester fetuses as well as neonates in order to examine whether the differences in production of HbA and F in the fetal and newborn ontogenetic stages reflect in vivo predetermined differences in commitment among erythroid progenitors. Cultures of erythroid progenitors from first and second tr...

INTRODUCTION Type 2 diabetes mellitus and hypertension are commonly associated chronic conditions which require regular structured treatment. In the UK many quality markers have been improved through an incentivisation scheme. The aim of this study was to discover if there is potential for improving the quality of care for patients with type 2 diabetes and hypertension in rural Italy, through a...

The level of glycosylated haemoglobin in the blood is considered as an index of long term blood glucose levels in diabetic patients. Glycosylation of structural proteins also occur. The present study describes the levels of glycosylated blood proteins (nonenzymatic) and blood glycoproteins (enzymatic glycosylation) in four groups of diabetic patients (n = 80) as well as non-diabetic control sub...

AIM Glycated haemoglobin (HbA1c), a marker of glucose control in individuals with diabetes mellitus, is also related with the incidence of cardiometabolic risk in populations free of disease. The aim of this study was to describe the distribution of HbA1c levels according to early-life and contemporary factors in adolescents and adults without diabetes mellitus. METHODS HbA1c was measured in ...

BACKGROUND Although the prevalence of diabetes is three to five times higher in UK South Asians than Whites, there are no reports of the extent of ethnicity recording in routine general practice, and few population-based published studies of the association between ethnicity and quality of diabetes care and outcomes. We aimed to determine the association between ethnicity and healthcare factors...