H EMOGLOBIN J was first reported in an American Negro family by Thorup et al.’ in 1956. Subsequently, it has been found in Indonesians,2’ East Indians,4’5 French-Canadians,6 Chinese,7 a Negro-Caucasian,5 and most recently in a family of Hawaiian-Chinese-Caucasian ancestry.’ The hemoglobin “Liberian I” described by Robinson et al.’” was formerly’ designated as hemoglobin J but recently has been ...

We tested the hypothesis that chemical modifications used to produce stable, oxygen-carrying, Hb-based blood substitutes can induce cytotoxicity in endothelial cells in culture because of altered redox activity. We examined the interaction of hydrogen peroxide with nonmodified hemoglobin (HbA0) and two chemically modified hemoglobins, α-cross-linked hemoglobin (α-DBBF) and its polymerized form ...

Hemoglobin synthesis in the erythropoietic tissues of 11 normal human fetuses ranging in age from 6 to 21 wk has been studied. The incorporation of 3H-labeled and ‘4C-Iabeled leucine, valine, and isoleucine into the separated hemoglobins has been measured, and rates of synthesis of hemoglobins Fo, Fi. and A determined. Hemoglobin A synthesis could be detected in all of the embryos studied and w...

T HE NATURE of the transition from hemoglobin F synthesis to hemoglobin A synthesis in the fetus and newborn remains unknown. Although it is evident from the elution method developed by Kleihauer, Braun and Betke13 that hemoglobin F and hemoglobin A may coexist in single erythrocytes,24 quantitative data regarding the amounts of these hemoglobins in individual cells are lacking. An attempt to q...

T HE NATURE of the transition from hemoglobin F synthesis to hemoglobin A synthesis in the fetus and newborn remains unknown. Although it is evident from the elution method developed by Kleihauer, Braun and Betke13 that hemoglobin F and hemoglobin A may coexist in single erythrocytes,24 quantitative data regarding the amounts of these hemoglobins in individual cells are lacking. An attempt to q...

Oxygen-binding properties of single red blood cells from the red-eared turtle Trachemys scripta were measured by microspectrophotometry to describe the variation in oxygen affinity of red blood cells and to gain insight into the distribution of functionally different hemoglobins among red blood cells. Methodologically, this study represents the first report on the cell-to-cell variation in oxyg...

The rates of binding and dissociation of CO and hybridheme hemoglobins, in which one chain contains protoheme and the other chain mesoor deuteroheme, were measured at each heme site independently of changes at the partner chain site. The rates were also determined on isolated chains. The binding reaction of CO to hybrid-heme hemoglobins follows an autocatalytic process characteristic of a heme-...

The rates of binding and dissociation of CO and hybridheme hemoglobins, in which one chain contains protoheme and the other chain mesoor deuteroheme, were measured at each heme site independently of changes at the partner chain site. The rates were also determined on isolated chains. The binding reaction of CO to hybrid-heme hemoglobins follows an autocatalytic process characteristic of a heme-...

The recent electrophoretic experiments of Pauling, Itano, Singer, and Wells (1) have demonstrated that the hemoglobins of normal Negroes and of sickle-cell anemics are unlike; in a buffer of suitable pH the two components of a mixture of these hemoglobins migrate in opposite directions. On the basis of the difference in their isoelectric points, it was concluded that the hemoglobin of sickle-ce...

Real options investments are expected to take their greatest value during periods of abnormally high uncertainty. This important proposition of real options is empirically difficult to test, since one cannot readily find such well-defined unanticipated periods affecting large numbers of firms. We attempt to address this problem in the real options literature by focusing on the case of Korean fi...