Hemolytic uremic syndrome (HUS) is a rare thrombotic complication characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS may be caused by several different conditions, including infection, malignancy, and chemotherapeutic agents, such as mitomycin, cisplatin, and most recently, gemcitabine. The outcome of gemcitabine-induced HUS is poor, an...

Hemoglobin D a hemoglobin variant occurs in a group of asianpopulation particularly from india, Pakistan, Iran, Iraq. In india, it is mainly reported in north western states of Haryana, PunJab and Gujarat. In heterozygous form, Hb D disease is mild and causes subclinical jaundice. In heterozygous form, it can cause severe hemolytic anemia. Here we present a similar case of Hb D with hemolytic j...

The methods of Lancefield and of Griffith for grouping and typing hemolytic streptococci have greatly facilitated studies on the relationship of the hemolytic streptococcus to human disease. Strains from human disease fall into Lancefield's Group A by the precipitin test.5 Exceptions occur, but they are rare.' Group A consists of about 30 types which can be identified by another precipitin test...

Hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. The atypical form of HUS is a disease characterized by complement overactivation. Inherited defects in complement genes and acquired autoantibodies against complement regulatory proteins have been described. Incomplete penetrance of mutations in all predisposing genes is r...

‘-I-’ HE DEVELOPMENT BY BIELSCHOWSKY1 of the NZB/Bl strain of I mice has provided a unique animal model for the study of autoimmune disease. ’#{176} The regular spontaneous appearance of Coombs-positive hemolytic anemia and other serologic markers of autoimmunity, the development of a lupus-like renal disease,4’7’11’12 and the results of therapy with immunosuppressive agents4” and splenectomy#{...

‘-I-’ HE DEVELOPMENT BY BIELSCHOWSKY1 of the NZB/Bl strain of I mice has provided a unique animal model for the study of autoimmune disease. ’#{176} The regular spontaneous appearance of Coombs-positive hemolytic anemia and other serologic markers of autoimmunity, the development of a lupus-like renal disease,4’7’11’12 and the results of therapy with immunosuppressive agents4” and splenectomy#{...

objective(s): streptococcus pyogenes produces extracellular hyaluronidase enzyme. this enzyme is directly associated with the spread of the organism during infection. the objective of the present study was to clone and express the nucleotide sequence of the enzyme which is involved in hyaluronidase enzymatic activity. materials and methods: the enzymatic region of hyaluronidase gene was detecte...

background diabetes mellitus as a chronic metabolic disease occurs in patients with partial or complete deficiency of insulin secretion or disorder in action of insulin on tissue. the disease is known to provide conditions for overgrowth of candida species. candida spp. cause candidiasis by many virulence factors such as esterase, hemolysin and phospholipase. objectives this study aimed to comp...

Sickle cell disease is a hereditary, autosomal recessive pathology caused by the replacement of adenine thymin in position 6 beta globin gene, producing anomalous hemoglobin (hemoglobin S- HbS). It characterized chronic inflammatory state with hemolytic anemia and vaso-occlusive phenomena occurs when HbS gene homozygosis (SS) or heterozygosis, association other variant hemoglobins (SD, SC, SE) ...

Infliximab is a monoclonal antibody that antagonizes the activity of tumor necrosis factor alpha to induce and maintain remission in patients with inflammatory bowel disease. Adverse effects associated with Infliximab infusions include infusion reactions, risk of infections, development of hematological malignancies, and pancytopenia. Autoimmune hemolytic anemia has rarely been reported in ulce...