An improved microwave coagulation (MC) method was devised for hemostasis after liver biopsy and puncture of the spleen under laparoscopy. Safety and hemostatic effects of the method were studied with the following results: 1) MC resulted in a wedge-shaped area around the electrode showing necrosis and degeneration of hepatic cells in the liver of five autopsied cases. The area of tissue damage ...

Plasma fibronectin (pFn) has long been suspected to be involved in hemostasis; however, direct evidence has been lacking. Here, we demonstrated that pFn is vital to control bleeding in fibrinogen-deficient mice and in WT mice given anticoagulants. At the site of vessel injury, pFn was rapidly deposited and initiated hemostasis, even before platelet accumulation, which is considered the first wa...

Bleeding hepatobiliary tumors can sometimes be critical in patients with advanced malignancy. Several methods can be used to achieve hemostasis, such as the placement of a covered metal stent or vessel coiling under angiographic control. If tumor bleeding occurs near the mid or lower bile duct, a fully coveredmetal stent can be placed for hemostasis; however, this method may be challenging if t...

Background and study aims  TC-325 (Hemospray, Cook Medical) is a powder agent for endoscopic hemostasis in patients with upper gastrointestinal bleeding (UGIB). Although most publications are based on case-reports and retrospective studies, data on efficacy are promising. Here we report our experience with TC-325 for diffuse or refractory UGIB. Patients and methods  Data on patients receiving...