Although excessive bleeding is widely recognized as a common complication of cardiac surgery, the recent success of antifibrinolytic drugs as prophylactic hemostatic agents has received little attention outside the surgical literature. The etiology of the coagulopathy following cardiac surgery is clearly multifactorial; however, the success of antifibrinolytic drugs as hemostatic agents suggest...

BACKGROUND Serious injuries accompanied by severe bleeding are life-threatening. Post-traumatic hemorrhage involves the risk of developing coagulopathy. Hemostatic dressings are widely used to minimize bleeding. The application of procoagulants in control of hemorrhage may lead to thrombosis or disseminated intravascular coagulation. The aim of this study was to evaluate the effect of hemostati...

BACKGROUND Hemostatic dressings are advanced topical dressings designed to control hemorrhage by enhancing clot formation. These dressings may be effective when used on injuries sustained in junctional zones. The Israeli Defense Forces Medical Corps (IDF-MC) chose to equip its medical personnel with the QuikClot Combat Gauze. There is a paucity of data describing clinical use and results of hem...

statement of problem: hemostatic agents may affect the micro-leakage of different adhesive systems. also, chlorhexidine has shown positive effects on micro-leakage. however, their interaction effect has not been reported yet. objectives: to evaluate the effect of contamination with a hemostatic agent on micro- leakage of total- and self-etching adhesive systems and the effect of chlorhexidine a...

By cutting gill filaments in anesthetized rainbow trout ( Oncorhynchus mykiss), observing the bleeding through a stereomicroscope, and using blockers of various known endogenous filament artery vasoconstrictors, we have here attempted to characterize hemostatic mechanisms in gills. The immediate hemostatic response to a cut in a gill filament artery was a local vasoconstriction, stopping the he...

The hemostatic efficacy, as well as the cardiovascular effects, of two hemostatic agents currently used during endodontic surgery was examined. The hemostatic agents used were epinephrine pellets (Racellet pellets) or 20% ferric sulfate (Viscostat). Patients were assigned to one of two experimental groups. Blood pressure and pulse rate were recorded pre- and postoperatively and at three additio...

Platelet accumulation is a hallmark of hemostasis and a contributing factor in heart attacks and strokes. Platelet activation is driven by receptor-mediated signaling in response to stimuli of varying potency, such as collagen, thrombin, adenosine 59-diphosphate (ADP), and thromboxane A2 (TxA2). This has led to a model of the hemostatic response in which redundant elements of the platelet-signa...

Platelets are small anucleated cells present only in mammals. Platelets mediate intravascular hemostatic balance, prevent interstitial bleeding, and have a major role in thrombosis. Activation of platelet purinergic receptors is instrumental in initiation of hemostasis and formation of the hemostatic plug, although this activation process becomes problematic in pathological settings of thrombos...

Pregnancy is a hypercoagulable state due to pro-hemostatic changes in the activity of coagulation factors and fibrinolysis progressively increasing pressure on iliac veins from growing uterus. Thus, it not surprising that there an increased risk for thrombotic events especially pelvic veins. With trauma delivery, particularly caesarian section, accentuated early days postpartum. Multiparity see...