results there were 64 women and 936 men in the population under study. the mean ± sd age of the donors was 38 ± 11 years. 80 out of 1000 samples (8%) were found to be positive for hbcab. hbv dna was detected in 50% of hbcab positive specimens. the mean ± sd age of donors without hbv dna was 37.7 ± 10.5 years and for donors with hbv dna was 40.9 ± 11.2 years (p = 0.05). objectives the aim of thi...

conclusions several previous studies used pcr-rflp to genotype hbv; however, we showed the high risk to obtain atypical profiles, especially in advanced stages of chronic infection, with as results difficulties to genotype the virus. these profiles resulted from the accumulation of mutations during natural course of infection resulting in a modification in restriction sites for enzymes. so, we ...

background occult hepatitis b virus infection (obi) is defined as the presence of hepatitis b virus (hbv) dna in the liver and/or in the serum of patients with negative results of hepatitis b s antigen (hbsag) test with or without serological markers of previous viral exposure. the impact of obi in patients with chronic hepatitis c (chc) is still unclear. objectives the aim of this study was to...

background in this study, we evaluated the prevalence of the most common mutations occurring in enhancer ii (enhii), basal core promoter (bcp), precore (pc), and core (c) regions of hepatitis b virus (hbv) genome. objectives we also investigated the correlation between hbv variants, their genotypes, and patients’ hbe antigen (hbeag: soluble shape of the capsid antigen) status patients and metho...

background: different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis b (hb) vaccine do not produce protective levels of anti-hb antibody, a phenomenon which could be linked to certain human leukocyte an-tigen (hla) class-ii alleles or haplotypes. objectives: the present study was under-taken to determine the frequency of hla class-ii alleles in ...

results the frequencies of the aa, at, and tt genotypes were 31%, 51%, and 18% in the chronic hbv patient group, and 40%, 45%, and 15% in the healthy control group, respectively. however, a lack of association of the + 874 polymorphism in the ifn-γ gene of those with chronic hbv infection was found. evaluation of hbv association with this polymorphism was significant under the dominant genetic ...

diagnosis of hepatitis b is routinely based on of serological assay of hepatitis b surface antigen (hbsag). occult hepatitis b virus (hbv) infection is generally defined as the detection of hbv -dna in the serum or tissues of subjects who have negative test for hbsag. transmission of hbv infection has been documented from hbsag negative, anti-hbc positive blood and organ donors. the aim of this...

background the presence of an infected family member significantly increases the risk of hbv transmission, but many socio-demographic and viral characteristics of family members affect the transmission rate. objectives in this study, we have used data mining techniques to investigate the impact of different variables in intrafamilial transmission of hbv infection. patients and methods demograph...

conclusions in conclusion, our observations indicated that pcdna3.1 (+)-hbv1.3c was superior to aav/hbv plasmid for establishment of persistent hbv infection by hi, in vivo, and this mouse model could be useful for studies of hepatitis virology and for the development of innovatory treatments for hbv infections. results in 60% of the mice injected with pcdna3.1 (+)-hbv1.3c, hbsag, hbeag, hbcag ...