نتایج جستجو برای: hepatic biomarkers
تعداد نتایج: 193044 فیلتر نتایج به سال:
One of the major goals of the Great Lakes Action Plan is to actively accumulate and assess toxicological information on persistent toxic substances found in the Great Lakes basin. As part of Health Canada's commitment to this plan, a review of biomarkers for the environmental contaminants polychlorinated biphenyls (PCBs) and polychlorinated dibenzodioxins/dibenzofurans (PCDDs/PCDFs) was conduct...
BACKGROUND AND AIMS Cystic Fibrosis associated liver disease (CFLD) develops in approximately 30% of CF patients. However, routine sensitive diagnostic tools for CFLD are lacking. Within this study, we aimed to identify new experimental biomarkers for the detection of CFLD. METHODS 45 CF patients were included in the study and received transient elastography. Differential regulation of 220 di...
BACKGROUND A metabolomic study of biomarkers associated with dimethylnitrosamine (DMN)-induced hepatic fibrosis in Sprague-Dawley rats was performed using GC-MS. The clinical chemistry of the collected blood and the histopathology of excised liver samples were examined, and urine samples were prepared by solvent extraction. RESULTS Through pattern analysis, the DMN-treated group was divided i...
BACKGROUND Plasma phospholipid concentrations of trans-palmitoleic acid (trans-16:1n-7), a biomarker of dairy fat intake, are inversely associated with incident type 2 diabetes in 2 US cohorts. OBJECTIVE The objective was to investigate whether the intake of trans-16:1n-7 in particular, or dairy fat in general, is associated with glucose tolerance and key factors determining glucose tolerance...
PURPOSE We conducted a single-arm phase II study of cediranib, a pan-VEGFR tyrosine kinase inhibitor, in patients with advanced hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN Patients with histologically confirmed measurable advanced HCC and adequate hematologic, hepatic, and renal functions received cediranib 30-mg orally once daily (4 weeks/cycle). The primary endpoint was progression-...
hydatid disease has a worldwide spreading. the most common site of the disease is the liver, lungs, kidney, bones, and brain. splenic hydatid disease has been reported to constitute 2% to 6% of patients with abdominal hydatid disease. because of the rarity of splenic hydatid disease, the probable concomitance of the liver and splenic hydatid cysts should be taken into consideration by clinician...
introduction and objective: liver is an important body organ without which life is impossible. cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. the present study aimed to find a suitable antioxidant and examine the effect of vitamin e and selenium on reducing the side effects of cyclophosphamide on liver as a vital organ....
Previous texture analysis studies of liver CT images have shown the potential to achieve hepatic malignancy or predict overall survival (OS). However, to date, most studies have mainly focused on assessing texture features of the noncontrast CT or portal-phase image in the dynamic contrast-enhanced CT sequence. The aim of this study was to quantify texture features of physiologically-based kine...
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