objective(s): our present study sought to evaluate hepatoprotective and antioxidant effects of methanol extract of azolla microphylla phytochemically synthesized gold nanoparticles (gnap) in acetaminophen (apap) - induced hepatotoxicity of fresh water common carp fish.materials and methods: gnap were prepared by green synthesis method using methanol extract of azolla microphylla.  twenty four f...

Acetaminophen (APAP) overdose induces acute liver injury. The aim of the present study was to analyze the difference of susceptibility between immature and adult mice to APAP-induced acute liver injury. Weanling immature and adult mice were injected with APAP (300 mg/kg). As expected, immature mice were more susceptible than adult mice to APAP-induced acute liver injury. APAP-evoked hepatic c-J...

background: the use of devices emitted microwave radiation such as mobile phones, wireless fidelity (wi-fi) routers, etc. is increased rapidly. it has caused a great concern; the researchers should identify its effects on people's health. we evaluated the protective role of vitamin c on the metabolic and enzymatic activities of the liver after exposure to wi-fi routers. material and methods: 70...

Abstract The present study evaluated the protective effects of silymarin extract (SIE) on cadmium chloride toxicity in common carp, Cyprinus carpio . Four experimental groups were considered for experiment including: SIE 0 (control): non-SIE-supplemented fish, 1 : fish supplemented with 400 mg SIE/kg diet, 2 1400 3 2400 diet. Fish fed diet 60 days and then exposed to (1.5 mg/l or 25% LC50-96 h)...

Cytoplasmic lipid droplets (CLD) are organelle-like structures that function in neutral lipid storage, transport and metabolism through the actions of specific surface-associated proteins. Although diet and metabolism influence hepatic CLD levels, how they affect CLD protein composition is largely unknown. We used non-biased, shotgun, proteomics in combination with metabolic analysis, quantitat...

The activity of the two folate dependent enzymes supplying carbon 2 and carbon 8 of the purine nucleus was assayed in the bone marrow of rats and man, as well as in rat livers. The activity of both enzymes was several fold greater in marrow than in liver. Inactivation of cobalamin by exposure to nitrous oxide did not affect the enzymes in rat marrow cells, although an appreciable effect on hepa...

The failure of pancreas transplantation to normalize plasma glucagon concentration and insulin: glucagon balance in portal blood has recently been demonstrated on streptozotocin-diabetic rats. The same experimental model was used in the present study to examine the effect of pancreas transplantation on liver carbohydrate metabolism. Twenty weeks after pancreas transplantation, the left hepatic ...

The effects of dietary phytol and the type of dietary fat on hepatic fatty acid oxidation were examined in male ICR mice. Mice were fed diets containing 0 or 5 g/kg phytol and 100 g/kg palm, safflower, or fish oil for 21 d. Among the groups fed phytol-free diets, the activities and mRNA abundance of various enzymes involved in fatty acid oxidation were greater in mice fed fish oil than in those...