Five human hepatitis viruses cause most of the acute and chronic liver disease worldwide. Over the past 25 years, hepatitis C virus (HCV) in particular has received much interest because of its ability to persist in most immunocompetent adults and because of the lack of a protective vaccine. Here we examine innate and adaptive immune responses to HCV infection. Although HCV activates an innate ...

The concept that human viral hepatitis was caused by no more than two etiologic agents stemmed from early volunteer studies in which two epidemiologically distinct types of hepatitis were transmitted to humans (1). These experimentally transmitted diseases closely resembled two forms of naturally occurring viral hepatitis that could be distinguished on epidemiologic grounds. One form was highly...

Five nonoverlapping antigenic sites (sites I through V) of woodchuck hepatitis virus surface antigen were identified with competitive binding assays involving monoclonal antibodies. Site I contributed to cross-reactions among surface antigens of hepatitis B-like viruses infecting woodchucks, ground squirrels, and humans. At least three distinct sites (sites I, II, and III) are responsible for c...

Blood-borne viruses, such as hepatitis B virus, hepatitis C virus, human immunodeficiency virus, and the facultative blood-borne hepatitis E virus, are considered a major public health problem given that they are accountable for millions of deaths each year. Treatment options, including effective vaccine design, development of antiviral strategies and the implementation of antiretroviral therap...

The World Health Organization (WHO) has adopted targets unanimously at the World Health Assembly in July 2016, in Geneva, to significantly curtail hepatitis B and C viruses to near extinction by 2030. Preparations are now ongoing in all WHO member nations across the globe to reach this ambitious, but perhaps achievable target. In Bangladesh, hepatologists, nongovernmental organizations, civil s...

INTRODUCTION The epidemiology of viral hepatitis during pregnancy is of paramount importance for health planners and program managers. Data on viral hepatitis during pregnancy are not readily available in many African and Arab countries. Both regions have their own unique geography, and comprise over 59 states with crossover and interaction of different cultures. METHODOLOGY A systematic elec...