نتایج جستجو برای: hepatocellular

تعداد نتایج: 54283  

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008
Chin-Liew Chong Shiu-Feng Huang Cheng-po Hu Ya-Ling Chen Hsin-Ying Chou Gar-Yang Chau Jin-Yuh Shew Yue-Lin Tsai Chiung-Tong Chen Chungming Chang Mong-Liang Chen

Previous studies have identified that the expression of UK114 is tissue specific and the protein has been found to be most abundant in liver and kidney. However, the expression of UK114 in human hepatocellular carcinoma and its relationship to differentiation and transformation of hepatocellular carcinoma have not been studied. In this study, the expression of UK114 in human hepatocellular carc...

Journal: :Cancer research 2014
Gianluigi Giannelli Erica Villa Michael Lahn

Hepatocellular carcinoma arises in patients as a consequence of long-standing preexisting liver illnesses, including viral hepatitis, alcohol abuse, or metabolic disease. In such preexisting liver diseases, TGF-β plays an important role in orchestrating a favorable microenvironment for tumor cell growth and promoting epithelial-mesenchymal transition (EMT). TGF-β signaling promotes hepatocellul...

2017
Bin Liu Jing Li Xiaoling Liu Min Zheng Ye Yang Qian Lyu Li Jin

Hepatocellular carcinoma has been identified as the fifth most common cancer in men and the ninth in women worldwide. Despite many efforts have been made in recent years, the overall survival rate of patients with hepatocellular carcinoma still remain unsatisfied. Therefore, exploring the mechanisms underlying the progression of hepatocellular carcinoma is essential for developing novel treatme...

2017
Shih-Wei Lai Kuan-Fu Liao Cheng-Li Lin Hsien-Feng Lin

Objectives: The purpose of the study was to assess the relationship between selective serotonin reuptake inhibitors use and hepatocellular carcinoma in Taiwan. Methods: Using the database of the Taiwan National Health Insurance Program, we conducted a case-control study to identify 4901 subjects aged 20 years and more with newly diagnosed hepatocellular carcinoma in 2000-2013 as the cases. We r...

Journal: :Gastroenterology 2002
Alex S Befeler Adrian M Di Bisceglie

Hepatocellular carcinoma is the most frequent primary malignancy of the liver and appears to be rising in incidence in the United States and other developed western countries. Imaging studies play a key role in diagnosis of hepatocellular carcinoma, and more and more commonly, patients are being diagnosed at an asymptomatic stage. The use of triphasic computed tomography scanning and improved m...

2014
Gianluigi Giannelli Erica Villa Michael Lahn

Hepatocellular carcinoma arises in patients as a consequence of long-standing preexisting liver illnesses, including viral hepatitis, alcohol abuse, or metabolic disease. In such preexisting liver diseases, TGF-b plays an important role in orchestrating a favorable microenvironment for tumor cell growth and promoting epithelial–mesenchymal transition (EMT). TGF-b signaling promotes hepatocellul...

Journal: :Cancer research 2005
Yuqing Liu Ronnie T Poon Qinyu Li Tsz Wai Kok Cecilia Lau Sheung Tat Fan

Vascular endothelial growth factor (VEGF) plays an important role in tumor angiogenesis of hepatocellular carcinoma. Inhibition of VEGF receptors could theoretically reduce angiogenesis and tumor growth in hepatocellular carcinoma, but this remains to be proven with an experimental study. This study examined the angiogenesis-dependent and angiogenesis-independent activities of PTK787/ZK222584 (...

2012
Moemen AK Abdalla Yousef Haj-Ahmad

Hepatocellular Carcinoma is a major healthcare problem, representing the third most common cause of cancer-related mortality worldwide. There are 130 million Hepatitis C virus infected patients worldwide who are at a high-risk for developing Hepatocellular Carcinoma. Due to the fact that reliable parameters and/or tools for the early detection of Hepatocellular Carcinoma among high-risk individ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Hirotaka Ito Shin-ichi Funahashi Naoko Yamauchi Junji Shibahara Yutaka Midorikawa Shigeto Kawai Yasuko Kinoshita Akira Watanabe Yoshitaka Hippo Toshihiko Ohtomo Hiroko Iwanari Atsushi Nakajima Masatoshi Makuuchi Masashi Fukayama Yuichi Hirata Takao Hamakubo Tatsuhiko Kodama Masayuki Tsuchiya Hiroyuki Aburatani

PURPOSE Hepatocellular carcinoma is the most common primary malignancy of the liver and accounts for as many as one million deaths annually worldwide. The present study was done to identify new transmembrane molecules for antibody therapy in hepatocellular carcinoma. EXPERIMENTAL DESIGN Gene expression profiles of pooled total RNA from three tissues each of moderately differentiated and poorl...

Journal: :Tumori 2010
Milena Kanazir Ivan Boricic Dragan Delic Darija Kisic Tepavcevic Aleksandra Knezevic Tanja Jovanovic Tatjana Pekmezovic

AIMS AND BACKGROUND The objective of this case-control study was to test the existing hypotheses about factors related to the occurrence of hepatocellular carcinoma in the population of Belgrade (Serbia). METHODS AND STUDY DESIGN The investigation was conducted between 2004 and 2007 and consisted of 45 newly diagnosed, histologically confirmed hepatocellular carcinoma patients and 90 individu...

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