PURPOSE Recent studies have shown that Dickkopf-1 (DKK-1) is overexpressed in some tumors, including hepatocellular carcinoma. However, the role of increased DKK-1 in these tumors is not known. In this study, the DKK-1 expression in hepatocellular carcinoma (HCC) cell lines was evaluated and the effect of DKK-1 overexpression in HCC cell lines was studied. MATERIALS AND METHODS The expression...

context several risk factors play the role in the development of hepatocellular carcinoma (hcc) from which chronic hepatitis b and c infections are the most important ones. dna integration of hepatitis viruses alters the function of critical genes promoting malignant transformation of virus-infected liver cells. evidence acquisition there are remarkable geographic differences in prevalence of c...

conclusions pivka-ii was as efficient as afp when used as a single marker for hcc screening and the combination of two biomarkers gave a better performance. results the sensitivity and specificity of pivka-ii were 74.6% and 67.8% at a cutoff of 40 mau/ml and 64.2% and 89.7% at a cutoff of 200 mau/ml. the sensitivity and specificity of afp were 76.7% and 65.0% at a cutoff of 20 ng/ml and 60.4% a...

BACKGROUND To compare the biological characteristics of three types of human hepatocellular carcinoma multi-drug resistant cell sub-lines Bel-7402/ADM models established by three methods. METHODS Established human hepatocellular carcinoma adriamycin (ADM) multi-drug resistant cell sub-lines models Bel-7402/ADMV, Bel-7402/ADML and Bel-7402/ADMS by three methods of in vitro concentration gradie...

introduction : fibrolamellar carcinoma (flc), a subtype of hepatocellular carcinoma (hcc), is a rare primary hepatic malignancy. several aspects of the clinical features and epidemiology of flc remain unclear since most literature on flc consists of case reports and small cases series with limited information on factors that affect survival. majority of the tumors occurred in patients less than...

In vitro the production of natural diosgenin from callus culture became an alternative biotechnological approach to production. This study describes effect plant growth regulators (PGRs) on induction and using different elicitors in induce (Diosgenin) parts Balanites Aegyptiacae extract cell lines. Root, stem, leaves calture B. aegyptiacae, were raised Murashing skoog Medium (MS) supplemented w...

A new series of 1,2-diaryl-4,5,6,7-tetrahydro-1H-benzo[d]imidazoles, possessing trimethoxy phenyl pharmacophore, were synthesized to evaluate their biological activities as tubulin inhibitors. Cytotoxic activity of the synthesized compounds 7a-f was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HEPG2 (liver hepatocellular cells), A549 (adenocarcinomic h...

Hepatitis B viral infection-induced hepatocellular carcinoma is one of the major problems in the developing countries. One of the HBV proteins, HBx, modulates the host cell machinery via several mechanisms. In this study we hypothesized that HBV enhances cell proliferation via HBx-induced microRNA-21 in hepatocellular carcinoma. HBx gene was over-expressed, and miRNA-21 expression and cell prol...

Radiofrequency thermal ablation (RFA) destroys tumoral tissue generating a local necrosis followed by marked inflammatory response with a dense T-cell infiltrate. In this study, we tested whether hepatocellular carcinoma thermal ablation can induce or enhance T-cell responses specific for hepatocellular carcinoma-associated antigens. Peripheral blood mononuclear cells derived from 20 patients w...

the chloroform soluble fractions of ethanolic extracts of five inula belonging to the compositae family were evaluated for cytotoxic activity against five different cell lines including caco2 (human colon adenocarcinoma), mcf7 (human breast adenocarcinoma), hepg2 (human hepatocellular carcinoma), vero (green african monkey kidney) and wehi164 (balb c mouse fibrosarcoma). cytotoxicity was assess...