Aim: To evaluate in vitro hepatoprotective activity of ethanolic extract from Corchorus depressus (CDEE) against CCl4 induced toxicity in HepG2 cell line. Methods: In vitro cytotoxicity and hepatoprotective potential of CDEE were evaluated using HepG2 cells. Based on the cytotoxicity assay, CDEE (50, 100, 200 mg/ml) was assessed for hepatoprotective potential against CCl4 induced toxicity by mo...

A novel series of 2-methyl-3-phenylquinazolin-4-one derivatives were synthesized and biologically evaluated for their cytotoxic potential against MCF-7, HepG2, PC-3 cancer cells. Most the tested compounds showed reasonable safety in normal human skin melanocyte HFB4 cell line. Compound 4 potent cytotoxicity on Hep-G2 lines, while compound 9 MCF-7 line, whereas 10 12 lines using 5-fluorouracil a...

OBJECTIVE Hyperglycemia, a common metabolic disorder in diabetes, can lead to oxidative damage. The use of antioxidants can benefit the control and prevention of diabetes side effects. This study aims to evaluate the effect of nanoceria particles, as an antioxidant, on glucose induced cytotoxicity, reactive oxygen species (ROS), lipid peroxidation (LPO) and glutathione (GSH) content in a human ...

CIAPIN1 is recently recognized as a key player in a variety of prevalent cancers. In this study, we sought to explore the correlation of CIAPIN1 expression with cell apoptosis in liver cancer cell line. SI CIAPIN1 was transfected into HepG2 and Huh7 cell line to interfere the expression of CIAPIN1. Real-time polymerase chain reaction (RT-PCR) was performed to determine the expression level of C...

A novel biotin-guided anticancer drug delivery system, prodrug , consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.

Two new platinum(II)-based complexes bearing a bone-targeting group were synthesized and characterized. They both have excellent affinity for hydroxyapatite (HA), which is abundant in human bone tissues. Their antitumor activities against five human cancer cell lines (U2OS, A549, HCT116, MDA-MB-231 and HepG2) were evaluated and compared with cisplatin (CDDP). Though the antitumor efficacies of ...

Hepatocellular carcinoma (HCC) is a hypervascular tumor and accumulating evidence suggests that angiogenesis plays an important role in HCC development. Cordycepin, also known as 3'-deoxyadenosine, is a derivative of adenosine, and numerous cellular enzymes cannot differentiate the two. The aim of the present study was to determine whether cordycepin regulates proliferation, migration and angio...

Tylophorine and its analogs are phenanthroindolizidine alkaloids, several of which have been isolated from the Tylophora genus of plants. Evaluation of ( )-S-tylophorine [DCB-3500 (NSC-717335)] and its analog DCB-3503 (NSC-716802) in the National Cancer Institute tumor screen showed a fairly uniform and potent inhibition of cell growth in all 60 cell lines (GI50 10 8 M). To further evaluate the...

BACKGROUND Cratoxylum formosum (Jack) Dyer ssp. pruniflorum (Kurz) Gogel. (Hóng yá mù) (CF) has been used for treatment of fever, cough, and peptic ulcer. Previously, a 50% ethanol-water extract from twigs of CF was shown highly selective in cytotoxicity against cancer cells. This study aims to investigate the molecular mechanisms underlying the apoptosis-inducing effect of CF. METHODS The cy...