نتایج جستجو برای: hereditary cancer syndrome
تعداد نتایج: 1562314 فیلتر نتایج به سال:
Renal cell carcinoma is one of the most common malignant neoplasms genitourinary system. Along with smoking and hereditary syndromes associated mutations in Von Hippel-Lindau (VHL) gene, obesity main risk factors for development renal carcinoma. Emerging data indicate a causal relationship between In large study within framework Metabolic Syndrome Cancer project, clinical on blood pressure, bod...
Cutaneous basal and squamous cell carcinomas are among the most frequent malignancies in the white population, with the annual incidence estimates ranging from 1 million to 3.5 million cases in the United States. These tumors can occur either sporadically or in the context of hereditary genodermatoses with cancer predisposition, such as basal cell nevus syndrome, xeroderma pigmentosum, epidermo...
641 O ncology is one of the first subspecialties to experience the full impact of the genomics revolution; oncology nurses regularly use genomic science in prevention, screening, diagnostics, prognostics, selection of treatment, and monitoring of treatment effectiveness in cancer care (Mahon, 2009). Genetic tests are now routinely ordered to determine risk for developing and appropriate managem...
Hereditary breast-ovarian cancer syndrome contributes to as much as 5-7% of breast cancer (BC) and 10-15% of ovarian cancer (OC) incidence. Mutations in the "canonical" genesBRCA1andBRCA2occur in 20-30% of affected pedigrees. In addition toBRCA1andBRCA2 mutations, germ-line lesions in theCHEK2,NBS1, andPALB2genes also contribute to familial BC clustering. The epidemiology of hereditary breast-o...
absract gastric cancer is the fourth most common cancer and the second leading cause of cancer death. most cases are sporadic and only 10% of patients, show familial clustering. among these patients, 1 to 3 % have hereditary diffuse gastric cancer (hdgc), which is autosomal-dominant and present in younger ages. mutations in ecadherin gene cdh1 has been identified in 30 to 50% of patients. becau...
Both cancer and metabolic disease have become the prevalent health risks in modern societies worldwide. Cancer is a complex set of illnesses with many definitions. About 15% cancers are caused by infections, 10% carry hereditary burden. The remaining 70%–75% associated variety processes, often syndrome chronic inflammation. This review examines role dysfunction inflammation development. I propo...
BACKGROUND Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance. In particular, patients with Lynch syndrome, hereditary nonpolyposis colorectal cancer (HNPCC), have an...
BACKGROUND Hereditary nonpolyposis colorectal cancer HNPCC, Lynch syndrome) is a genetic disease of autosomal dominant inheritance. It is caused by a mutation in one of four genes of the DNA mismatch repair system and confers a markedly increased risk for various types of cancer, particularly of the colon and the endometrium. Its prevalence in the general population is about 1 in 500, and it ca...
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