In the course of a survey of over a thousand children weighing 4 lb. (1,800 g.) or less at birth, there was an opportunity to investigate the occurrence of deafness in these children. This survey was made with the Society of Medical Officers of Health and was undertaken primarily to study the aetiology of cerebral palsy (McDonald, 1963). Deafness sufficient to require special schooling is very ...

In the course of a survey of over a thousand children weighing 4 lb. (1,800 g.) or less at birth, there was an opportunity to investigate the occurrence of deafness in these children. This survey was made with the Society of Medical Officers of Health and was undertaken primarily to study the aetiology of cerebral palsy (McDonald, 1963). Deafness sufficient to require special schooling is very ...

Mutations of the unconventional myosins genes encoding myosin VI, myosin VIIA and myosin XV cause hearing loss and thus these motor proteins perform fundamental functions in the auditory system. A null mutation in myosin VI in the congenitally deaf Snell's waltzer mice (Myo6(sv)) results in fusion of stereocilia and subsequent progressive loss of hair cells, beginning soon after birth, thus rei...

background: kallmann syndrome (kal s) is an isolated form of hypogonadotrophic hypogonadism in combination with a defect in smell sensation. depending on the genetic form of the disease, a number of non-reproductive, non-olfactory abnormalities may also be existent. in the present report, we describe a male with kal s associated with hearing loss, and the successful treatment of his sexual and ...

In mammalian development, the ear arises from a co-alescence of ectoderm, mesoderm, endoderm, and neu-ral crest–derived cells. Initially, an ectodermal placode invaginates to form a pouch of cells called the otocyst. The otocyst resides between the first and second bra-chial arches of the embryo. Paraxial mesoderm and neu-Boston, Massachusetts 02115 ral crest that underlie the epithelial coveri...