Imagine a world where nature and society coexist in a healthy symbiosis, where human impacts on the environment are minimal, and where communities are safe from natural and technological hazards. Imagine a time when scientists can monitor such sustainable human–environment interactions, when they can interactively share and compare data, analyses, and ideas about those interactions from their h...

In this paper we will discuss different types of control over synthetic characters in interactive stories. We will argue that, to attain a deeper and more engaging control, in certain conditions, users should be able to inspect, disclose, and modify the characters minds. To illustrate this idea, we will present a collaborative virtual environment called Teatrix, designed for children to build t...

Three new species of Isotomidae springtails are described from the Lake Champlain Basin (Vermont and New York, USA), Lake Willoughby and Greater Averril Pond in Vermont. Subisotoma joyceisp. n. and Scutisotoma champisp. n. were collected in sandy beaches whereas Ballistura rossisp. n. was found only in a constructed wetland built and managed by the University of Vermont. Scutisotoma champisp. n...

No abstract available.

José Rizal (1861-1896) is one of the most revered figures in Philippine history. He was a multifaceted intellectual and a political activist, best known for his political writings that inspired the Philippine revolution and ultimately led to his execution by the Spanish colonizers. Rizal was also a physician who trained in ophthalmology under 2 prominent European ophthalmologists, Louis de Weck...

150 years ago last month, The Lancet published an obituary: " DR JOHN SNOW—This well-known physician died at noon on the 16th instant, at his house in Sackville-street, from an attack of apoplexy. His researches on chloroform and other anaesthetics were appreciated by the profession. " John Snow's death was sudden and early—he was only 45 years of age. Other obituaries and eulogies were more ef...

This Focus Issue explores autophagic responses to stress in cardiometabolic disease, reveals how autophagy limits pathological hypertrophy in the heart, and describes how autophagy itself can regulate transcriptional responses to stress.