Human herpesvirus 8 (HHV-8) infection was identified in 6 out of 90 (6.7%) female commercial sex workers from Imbituba, Santa Catarina, and was associated to age. Frequencies of 5.6% of anti-latent and 3.3% of anti-lytic antibodies were detected. Considering non-endemic areas from Brazil, the anti-latent antibodies frequency seems elevated and requires further investigation on referent female p...

7. Mazzi R, Parisi SG, Sarmati L, et al. Efficacity of cidofovir on human herpesvirus 8 viraemia and Kaposi’s sarcoma progression in two patients with AIDS. AIDS. 2001;15:2061-2062. 8. Martin DF, Kuppermann BD, Wolitz RA, et al. Oral ganciclovir for patients with cytomegalovirus retinis treated with a ganciclovir implant. N Engl J Med. 1999; 340:1063-1070. 9. Parravicini C, Chandran B, Corbelli...

Herpesviruses are main sculptors of natural killer (NK) cell repertoires. While the ?-herpesvirus human cytomegalovirus (CMV) drives accumulation adaptive NKG2C-positive NK cells, ?-herpesvirus Epstein–Barr virus (EBV) expands early differentiated NKG2A-positive cells. cells support immunity by antibody-dependent cellular cytotoxicity, seem to preferentially target lytic EBV replicating B The i...

Cyclin D family members are cellular protooncogenes, and their viral homologues in the Kaposi's sarcoma-associated herpesvirus (KSHV, human herpesvirus type 8 [HHV-8]) and the closely related Herpesvirus saimiri have been implicated as putative cofactors of viral transformation and pathogenesis. KSHV is regularly found in Kaposi's sarcoma and in the primary effusion B cell lymphoma and Castlema...

Castleman disease (CD) is a lymphoproliferative disorder of unknown etiology that is associated with the development of secondary tumors, including B-cell lymphoma. Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus) sequences have been described in some cases of multicentric Castleman disease (MCD). Using a monoclonal antibody against an HHV-8-latent nuclear antigen, we show ...