A recent Keystone symposium on 'Stem Cell Interactions with their Microenvironmental Niche' was organized by David T. Scadden and Allan C. Spradling. The meeting was held in conjunction with another Keystone symposium, 'Stem Cells and Cancer', at Keystone, Colorado. Among the work that was presented at this meeting, scientists presented data that advances our understanding of the contribution t...

Although much has been learned concerning the mechanisms of secretory vesicle formation and fusion at donor and acceptor membrane compartments, relatively little attention has been paid toward understanding how cells maintain a homeostatic membrane balance through vesicular trafficking. In neurons and neuroendocrine cells, release of neurotransmitters, neuropeptides, and hormones occurs through...

For practical construction of complex synthetic genetic networks able to perform elaborate functions it is important to have a pool of relatively simple modules with different functionality which can be compounded together. To complement engineering of very different existing synthetic genetic devices such as switches, oscillators or logical gates, we propose and develop here a design of synthe...

Are P and NP provably inseparable ? Take a look at some unorthodox, guilty mentioned folklore and related unpublished results.

Services and relationship marketing are inextricably linked, such that the intangible, heterogeneous, inseparable, perishable nature of services renders strong relational bonds between companies customers particularly critical. Four high-level strategies observed in current business practice bear potential fundamentally altering how service providers build nurture relationships with their custo...

a mild and green method has been developed for the preparation of coumarins derivatives through the one-pot reactions. in our study,various phenols and ethyl acetoacetate compound in which we used silica-supported boron sulfonic acid [sio2/b(so4h)3] as a new, highly efficient and tri-functional inorganic brønsted acid catalyst were processed under solvent-free condition and thermal. the catalys...