We evaluate the performance of a Fast Ethernet network configured with a single large switch, a single hub, and a 4x4 2D torus topology in a testbed cluster of “commodity” Pentium Pro PCs. We also evaluated a mixed network composed of ethernet hubs and switches. An MPI collective communication benchmark, and the NAS Parallel Benchmarks version 2.2 (NPB2) show that the torus network performs bes...

We evaluate the performance of a Fast Ethernet network configured with a single large switch, a single hub, and a 4x4 2D torus topology in a testbed cluster of “commodity” Pentium Pro PCs. We also evaluated a mixed network composed of ethernet hubs and switches. An MPI collective communication benchmark, and the NAS Parallel Benchmarks version 2.2 (NPB2) show that the torus network performs bes...

Alzheimer's disease (AD) is a progressive neurodegenerative disease involving the alteration of gene expression at the whole genome level. Genome-wide transcriptional profiling of AD has been conducted by many groups on several relevant brain regions. However, identifying the most critical dys-regulated genes has been challenging. In this work, we addressed this issue by deriving critical genes...

Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC). Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with tumor node metastasis (TNM) staging of BC patients. Functional enrichment analysis was conducted to functionally annotate the hub genes. Protei...

In this paper, we present a novel multi-objective mathematical model for capacitated single allocation hub location problem. There are the vehicle capacity constraint and capacity restrictions amount of the incoming flow to the hub while the balancing requirements of incoming quantities of flow to the each hub is considered. Moreover, there is a set of available capacities for each potential hu...

We examine two factors that might explain the extent of air traffic delays in the United States: network benefits due to hubbing and congestion externalities. Airline hubs enable passengers to cross-connect to many destinations, thus creating network benefits that increase in the number of markets served from the hub. Delays are the equilibrium outcome of a hub airline equating high marginal be...

The rapid growth of the intercity travel demand has resulted in enormous pressure on passenger transportation network a megaregion area. Optimally locating hubs and allocating demands to influence effectiveness network. This study develops hierarchical hub location model considering service availability hubs. A mixed integer linear programming formulation was developed minimize total cost opera...

abstract one of the basic assumptions in hub covering problems is considering the covering radius as an exogenous parameter which cannot be controlled by the decision maker. practically and in many real world cases with a negligible increase in costs, to increase the covering radii, it is possible to save the costs of establishing additional hub nodes. change in problem parameters during the pl...

Microarray data were collected from bile duct samples from subjects with malignant biliary strictures by endoscopic retrograde cholangiopancreatography to screen for key genes associated with this disease. A predicted interaction network was constructed for these genes to interpret their functions. The gene expression dataset GSE34166 (10 samples: 6 malignant and 4 benign control samples) was d...

In contrast to p-hub problems with a summation objective (p-hub median), minmax hub problems (p-hub center) have not attained much attention in the literature. In this paper, we give a polyhedral analysis of the uncapacitated single allocation p-hub center problem (USApHCP). The analysis will be based on a radius formulation which currently yields the most efficient solution procedures. We show...