نتایج جستجو برای: high dose interferon
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background: interferons (ifns) are common therapeutics for several diseases such as viral hepatitis, multiple sclerosis and malignancy. a variety of autoimmune related side effects have been observed during ifn therapy. rare cases of myopathy, polymyositis or dermatomyositis have been reported during therapy with high doses of ifn^5. case presentation: in this report, we describe a case with se...
High levels of natural killer (NK) cell activity and high titers of interferon were observed in the peritoneal exudate of C57BL/6 mice 20 to 50 h after injection of mouse hepatitis virus type 3 (MHV3) but not during the first 10 h after infection. C57BL/6 mice were susceptible to MHV3 infection and showed high titers of MHV3 in the peritoneal exudate 48 h after infection. A/J mice, in contrast,...
Pretreatment of chicken embryo cells with homologous but not heterologous interferon inhibits the synthesis of vaccinia virus early messenger ribonucleic acid (mRNA). This inhibition is seen in the presence of cycloheximide, i.e., in the absence of protein synthesis, suggesting that the virion-bound transcriptase may be the target of the antiviral activity associated with interferon treatment. ...
background cutaneous leishmaniasis is a health problem in the world. lesions should be treated on cosmetically or functionally important sites, such as the face and hands. cantharidin is a terpenoid compound produced naturally by beetles of meloidae and oedemeridae families. objectives the current study aimed to investigate the effect of cantharidin on cutaneous leishmaniasis (cl) lesions and i...
Background: Pharmacological therapies of proven efficacy in corona virus disease 2019 are still lacking with no antiviral treatment. Impaired type I interferon activity may be responsible for severe COVID-19 patient. We performed prospective, observational, open-label study to evaluate the and safety a single dose Pegylated IFN-α2b addition Remdesivir moderate cases. Aim: The aim this is assess...
Interferon beta 6 million units per week was administered to a patient with an aggressive astrocytoma in the tectum that was resistant to cisplatin, etoposide, vinblastine, and the oral alkylating agent temozolomide. The tumor was immunopositive for O6-methylguanine-DNA methyltransferase (MGMT). Interferon beta caused the disappearance of the gadolinium-enhanced lesion in the tectum. Interferon...
BACKGROUND The effect that high-dose interferon (IFN)-alpha induction therapy for hepatitis C virus (HCV) infection has on cellular immune responses is currently unknown. METHODS Thirty-one treatment-naive patients with chronic HCV infection received amantadine and ribavirin, combined with 6 weeks of high-dose IFN-alpha-2b induction therapy followed by weekly pegylated IFN-alpha-2b, for 24 or...
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