The aim of this study was to investigate the release characteristics of matrix (non-disintegrating) granules consisting of diltiazem hydrochloride (model drug) and glyceryl behenate (a wax matrix forming polymer) for sustained release application using sintering technique. The granules of diltiazem hydrochloride-wax matrix were prepared by melt granulation technique. This was formed by triturat...

determining biological equivalence between pioneer and generic products, checking equivalence after change in batch size, detecting changes in components or composition, and checking equivalence after modification of manufacturing equipment or processes. The test method has also been suggested as a possible standard for quality control of topical drug products. We thus established an in vitro d...

The study was aimed at developing extended release matrix tablets of poorly water-soluble diclofenac sodium and highly water-soluble metformin hydrochloride by direct compression using cashew gum, xanthan gum and hydroxypropylmethylcellulose (HPMC) as release retardants. The suitability of light grade cashew gum as a direct compression excipient was studied using the SeDeM Diagram Expert System...

K. Abe, K. Abe, R. Abe, T. Abe, I. Adachi, Byoung Sup Ahn, H. Aihara, M. Akatsu, Y. Asano, T. Aso, V. Aulchenko, T. Aushev, A. M. Bakich, Y. Ban, E. Banas, S. Behari, P. K. Behera, A. Bondar, A. Bozek, T. E. Browder, B. C. K. Casey, P. Chang, Y. Chao, B. G. Cheon, R. Chistov, S.-K. Choi, Y. Choi, L. Y. Dong, A. Drutskoy, S. Eidelman, V. Eiges, Y. Enari, F. Fang, H. Fujii, C. Fukunaga, M. Fukush...

1(NAFETIC) Centre, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, Andhra Pradesh, India. A b s t r a c t Ofloxacin (OFX) is a synthetic broad spectrum analog of second generation fluoroquinolone antibiotic. It is used for the treatment of urinary tract, prostate, skin, urinary and respiratory tract infections. Ornidazole (ORN) is a nitroimidazole derivativ...

A multiparticulate system was developed using the coating pan method with nonpareil seed as the core material for the Theophylline. The drug loaded pellets were prepared by powder layering technique, sprinkling the drug on the nonpareil seeds using PVP K-30 in IPA as binder. The drug loaded pellets were coated by using polymers ethyl cellulose, EUDRAGITRS:RL (2:1) and EUDRAGIT® RS:RL (3:1). The...

K. Abe, K. Abe, R. Abe, T. Abe, I. Adachi, Byoung Sup Ahn, H. Aihara, M. Akatsu, Y. Asano, T. Aso, V. Aulchenko, T. Aushev, A. M. Bakich, Y. Ban, E. Banas, S. Behari, P. K. Behera, A. Bondar, A. Bozek, T. E. Browder, B. C. K. Casey, P. Chang, Y. Chao, B. G. Cheon, R. Chistov, S.-K. Choi, Y. Choi, L. Y. Dong, A. Drutskoy, S. Eidelman, V. Eiges, Y. Enari, F. Fang, H. Fujii, C. Fukunaga, M. Fukush...

The aim of the current study was to formulate Fexofenadine hydrochloride loaded sustained release microspheres using HPMC K100 M CR, a release retardant hydrophilic polymer by solvent evaporation method. The effect of different drug loading on drug content, drug encapsulation efficiency and release of drug was monitored. The studies on in vitro release mechanism were performed using USP paddle ...

BACKGROUND This study investigated the relationship between dental occlusion and arm strength; in particular, the imbalance in the jaw can cause loss in arm strength phenomenon. One of the goals of this study was to record the maximum forces that the subjects can resist against the pull-down force on their hands while biting a spacer of adjustable height on the right or left side of the jaw. Th...