The influence of excipients on the disintegration times of tablets and the release of papaverine hydrochloride (PAP) from tablets were studied. Ten different formulations of tablets with PAP were prepared by direct powder compression. Different binders, disintegrants, fillers, and lubricants were used as excipients. The release of PAP was carried out in the paddle apparatus using 0.1 N HCl as a...

tionen des lignins bei der Sulfatkochung. II. Modellversuche zur Spaltung von Arylalkyllatherbindingungen durch Alkali. Acta Chem. Scand. 16: 1713-29. 8. HANSON, K. R. AND .M. ZUCKER. 1963. The biosynthesis of chlorogenic acid and related conjugates of the hydroxycinnamic acids. J. Biol. Chem. 238: 1105-15. 9. HIGUCHr, T. 1957. Biochemical studies of lignin formation. II. Pihysiol. Plantarum 10...

By using a synthetic deoxyoligonucleotide probe designed to recognize the structural gene for cytochrome cc3 from Desulfovibrio vulgaris Hildenborough, a 3.7-kb XhoI genomic DNA fragment containing the cc3 gene was isolated. The gene encodes a precursor polypeptide of 58.9 kDa, with an NH2-terminal signal sequence of 31 residues. The mature polypeptide (55.7 kDa) has 16 heme binding sites of th...

Bi-specific OMT (EC 2.1.1.68) catalyzes the meta-specific methylation of caffeic acid and 5-hydroxyferulic acid to ferulic acid and sinapic acid, respectively (Higuchi, 1990). It is one of the key enzymes in angiosperm dicots mediating the formation of unique precursors for syringyl lignin, which is generally absent in gymnosperms (Higuchi, 1990). OMT has been purified and its cDNA clones isola...

This paper describes an evolvable hardware (EHW) system for generalized neural network learning. We have developed an ASIC VLSI chip, which is a building block to configure a scalable neural network hardware system. In our system, both the topology and the hidden layer node functions of a neural network mapped on the chips are dynamically changed using a genetic algorithm. Thus, the most desira...

Objective: The study is centered on formulation and evaluation of low viscosity metronidazole gel with varying amount Carbopol. Methods: Formulations (F1, F2 F3) Metronidazole in form were done amounts Prepared gels inspected for surface pH, viscosity, spreadability, antimicrobial susceptibility, drug content percentage, vitro process release, release kinetics stability testing. Findings: Formu...

Objective(s): The quantitative calculation of release data is more facil when mathematics come to help. mathematically modeling could aid optimizing and amending the delivery systems design. Aim of this study is to find out the isoniazid release kinetic. Methods: In this work degradable temperature sensitive dextran-hydroxy ethyl me...