Morphine’s effects on learning and memory processes are well known to depend on synaptic plasticity in the hippocampus. Whereas the role of the hippocampus in morphine-induced amnesia and state-dependent learning is established, the biochemical and molecular mechanisms underlying these processes are poorly understood. The present study intended to investigate whether administration of morphine ...

Background: Matrix metalloproteinase-9 (MMP-9) expression has been implicated in molecular mechanisms of neurodegenerative disorders, and its abnormal level has been reported in Alzheimer’s disease (AD). Some protective mechanisms of statins against neurodegeneration might be mediated by the inhibition of MMP-9 expression. Here, we investigated the effect of simvastatin, on the hippocampal MMP-...

INTRODUCTION Bipolar disorder (BD) is a psychiatric disorder accompanied by deficits in declarative memory. Given the importance of the hippocampus in declarative memory, it is not surprising that BD patients have been reported to show hippocampal abnormalities. OBJECTIVES Review evidence about structural and functional hippocampal abnormalities in BD. METHODS Systematic review of studies c...

PURPOSE To establish the optimal imaging parameters and MR features of hippocampal sclerosis. METHODS Twenty-five outpatients with intractable temporal lobe epilepsy and 10 control subjects were studied at 1.5T. Four features of hippocampal abnormality were specifically evaluated; increased hippocampal signal on T2-weighted images, decreased signal on T1-weighted images, hippocampal atrophy, ...

Purpose: To study the protective effect of oxytocin on hypoxic-ischemic brain neuron injury in neonatal rats, and mechanism action involved.Methods: Hippocampal slices from SD rats were cultured oxygen/glucose-deprived (OGD) solution, leading to establishment model hippocampal vitro. The assigned 3 groups: control (ACSF solution), (OGD solution + 1 μM oxytocin). vertebral neurons CA1 region HIB...

Neuropsychiatric lupus (NPSLE), a manifestation of the autoimmune disease systemic erythematosus (SLE), is characterized by psychiatric symptoms including anxiety and depression upregulated autoantibodies. The B6.Nba2 spontaneous mouse model develops SLE, but has not previously been tested for NPSLE. We investigated NPSLE phenotype in male female mice (n = 12 each) age- sex-matched B6 controls ...

Background: Hippocampal volume has sharp rise till age of 2 years; then it rises slowly. Objective: To build a reference for hippocampus among Sudanese population. Method: It was comparative cross-sectional facility base study; with total coverage 65 patients attending Elmoalem Hospital, 3D MRI brain, during (December 2021 –April 2022). Dependent variable hippocampal and independent personal da...

• Patients with depression have higher attachment avoidance and anxiety Depression severity correlates the extent of avoidant anxious High is linked to smaller hippocampi parahippocampal cingulum alterations Results suggest a role hippocampal network for Insecure style (anxious avoidant) predisposes development has been in healthy individuals. However, it unclear if there are hippocampus (PHC) ...

background and objective: alzheimer’s disease (ad) is a neurodegenerative disorder specified by deposition of b-amyloid (ab) and neuronal loss that leads to learning and memory disturbances. one of the most important causes of ad is glutamate-dependent excitotoxicity in brain regions that is vulnerable to ad. according to previous reported results, it was revealed that riluzole, as a glutamate ...