Interaction between implant surface and surrounding bone influences implant fixation. We attempted to improve the bone-implant interaction by 1) adding surface micro scale topography by acid etching, and 2) removing surface-adherent pro-inflammatory agents by plasma cleaning. Implant fixation was evaluated by implant osseointegration and biomechanical fixation.The study consisted of two paired ...

AIM The aim of this study was to investigate the consequences of different flapless procedures for the installation of dental implants on peri-implant bone response. MATERIALS AND METHODS After bilateral extraction of the mandibular second and third premolars and a 3-month healing period, 30 SLActive(®) implants were installed for 3 months in 10 Beagle dogs according to three different surgic...

BACKGROUND Acyclovir (ACV), a synthetic purine nucleoside analogue, is known to be toxic to gonads. OBJECTIVE The current study evaluated cytotoxicity of ACV on histopathological changes in testis tissue and serum testosterone and lipid peroxidation concentrations of male rats. MATERIALS AND METHODS Animals were divided into five groups. One group served as control and one group served as c...

BACKGROUND Initial micromotion of a total hip replacement is associated with aseptic loosening. The use of bisphosphonates could be one way to reduce peri-implant bone resorption induced by micromotion. Bisphosphonates compounds are inhibitors of bone resorption. The aim of this study was to investigate whether local treatment with bisphosphonate would reduce bone resorption and fibrous tissue ...

The present study investigated the influence of granule size of 2 biphasic bone substitutes (BoneCeramic® 400-700 μm and 500-1000 μm) on the induction of multinucleated giant cells (MNGCs) and implant bed vascularization in a subcutaneous implantation model in rats. Furthermore, degradation mechanisms and particle phagocytosis of both materials were examined by transmission electron microscopy ...

Previously reported studies from this laboratory revealed that rats chronically intoxicated with lead (Pb) under hypoxic conditions (HX) impaired growth parameters and induced damages on femoral and mandibular bones predisposing to fractures. We also described periodontal inflammatory processes under such experimental conditions. Periodontitis is characterised by inflammation of supporting tiss...

Introduction Low dose methotrexate treatment (10-25 mg./week) is today considered the first choice disease-modifying agent (DMARD) for adult and juvenile rheumatoid arthritis. Methotrexate (MTX) has proven to be a safe and effective drug with relatively few side effects. Being a folate antagonist, MTX was originally designed for use in the treatment of malignancy. From the oncological practice,...

OBJECTIVE To determine the effects of topical administration of 20% oltipraz solution on histomorphometrical and stereological aspects of skin tissue in full thickness skin wounds in laboratory rats. METHODS Thirty-six male Wistar portion rats (220±20 g) were randomly divided into three groups (n=12). On the first day of experimentation, a 1-cm2 circular wound was made on the posterior surfac...

The purpose of our study was to test the effectiveness of Ostim nanocrystalline hydroxyapatite paste and Cerabone ceramic by treating a critical size bone defect (CSD) on the right foreleg of a white New Zealand rabbit. Evaluation was carried out by comparing four groups each with a different CSD filling: an only OSTIM bone filling, an only Cerabone filling, an OSTIM-Cerabone combination, and a...