نتایج جستجو برای: hiv i
تعداد نتایج: 1238862 فیلتر نتایج به سال:
The human immunodeficiency virus type 1 (HIV-1) vpu gene encodes a small integral membrane phosphoprotein with two established functions: degradation of the viral coreceptor CD4 in the endoplasmic reticulum (ER) and augmentation of virus particle release from the plasma membrane of HIV-1-infected cells. We show here that Vpu is also largely responsible for the previously observed decrease in th...
Innate immune sensing of viral infection results in type I interferon (IFN) production and inflammasome activation. Type I IFNs, primarily IFN-α and IFN-β, are produced by all cell types upon virus infection and promote an antiviral state in surrounding cells by inducing the expression of IFN-stimulated genes. Type I IFN production is mediated by Toll-like receptor (TLR) 3 in HCV infected hepat...
Human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) (HIV I AIDS) is a major public health problem in Zambia. Despite some evidence that the pandemic may have reached a plateau or perhaps has begun to decline at the national level, HIV continues to increase in different sub-populations such as adults above 19 years old. The characterization of the spatial patterns of...
BACKGROUND HLA-DR*04 was identified as a predictor of HIV-Associated neurocognitive disorder (HAND), low CD4 T-cell responses to HIV, and low plasma HIV RNA levels in a U.S. cohort. We hypothesized that low CD4 T-cell activation leads to poor immune control of HIV in the CNS, predisposing to HAND, but also provided fewer target (activated CD4 T-cells) for HIV replication. To assess the consiste...
Interferon alpha (IFN-alpha) induces significant antiretroviral activities that affect the ability of human immunodeficiency virus (HIV) to infect and replicate in its principal target cells, CD4+ T cells and macrophages. A major endogenous source of IFN-alpha during any infection is the macrophage. Thus, macrophages have the potential to produce both IFN-alpha and HIV. In this study, we examin...
This review summarizes the data on the anti-human immunodeficiency virus (HIV) activity associated with saliva and the possible routes of oral transmission of HIV. Saliva can be passed from an HIV-infected individual to an uninfected person via sexual or non-sexual activities. The relative risk of HIV transmission through saliva is a subject of continuing concern for dental practitioners. HIV-i...
بازدارنده های غیرنوکلئوزیدی نسخه بردار معکوس، یک طبقه جدید از داروهای ضد رتروویروسی هستند که برای درمان عفونت ویروس نقص ایمنی اکتسابی(hiv) استفاده می شوند. این بازدارنده ها از فعالیت آنزیم نسخه بردار معکوس که تکثیر ژنوم hiv را درکنترل دارد، جلوگیری می کنند. در بخش اول پروژه، مدل های qsar برای پیش بینی فعالیت ضد hiv یکسری از آنالوگ های فنتیل تیازولیل تیواوره (pett) که به عنوان بازدارنده های غیرن...
In response to critical turns in knowledge production, scholars of African descent have developed culturally responsive arts-based methodologies. Congruent with research is incorporating home knowing practices such as the poetics many and Africentric storytelling practices. This article presents my reflections a Canadian researcher on “re-finding” poetic inquiry interpret, represent, re-tell HI...
s of the 8th HIV Persistence during Therapy Workshop Session 1: Basic science of HIV latency I
هدف از پژوهش حاضر مقایسه ابعاد شخصیتی (برون گرایی، روان رنجورخویی و روان پریش خویی) و نیز بهزیستی ذهنی بیماران مبتلا به hiv و افراد غیر مبتلا است. جامعه آماری در این پژوهش عبارت است از کلیه بیماران مرد مبتلا به hivکه به مراکز پزشکی سطح شهر تهران مراجعه کرده بودند. نمونه مورد پژوهش 50 نفر بیمار مرد مبتلا بهhiv و 50 نفر مرد غیر مبتلا به hivبودند. گروه بیماران مبتلا بهhiv از بین بیماران مراجعه ...
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