conclusions although significant differences (p < 0.01) were observed in the frequency of ttmdv/sav between healthy controls and each of the hiv positive and hiv/hcv co-infected individuals, no significant difference was observed between hiv positive and hiv/hcv co-infected cases, which may be due to hiv associated immunodeficiency. this is the first time that ttmdv/sav is reported in hiv infec...

BACKGROUND Understanding the role of different classes of T cells during HIV infection is critical to determining which responses correlate with protective immunity. To date, it is unclear whether alterations in regulatory T cell (Treg) function are contributory to progression of HIV infection. METHODOLOGY FOXP3 expression was measured by both qRT-PCR and by flow cytometry in HIV-infected ind...

BACKGROUND Little is known about the time to sputum culture conversion in MDR-TB patients co-infected with HIV, although such patients have, historically, had poor outcomes. We describe culture conversion rates among MDR-TB patients with and without HIV-co-infection in a TB-endemic, high-HIV prevalent, resource-limited setting. METHODS Patients with culture-proven MDR-TB were treated with a s...

Unlike HIV-1-infected people, most HIV-2-infected subjects maintain a healthy CD4+ T cell count and a strong HIV-specific CD4+ T cell response. To define the cellular immunological correlates of good prognosis in HIV-2 infection, we conducted a cross-sectional study of HIV Gag-specific T cell function in HIV-1- and HIV-2-infected Gambians. Using cytokine flow cytometry and lymphoproliferation a...

human immunodeficiency virus (hiv) infection has been associated with cardiac disease, including anatomical or functional disturbance to the heart. cardiomyopathy (cmp) is one of these disturbances that have been associated with high rates of morbidity and mortality. in this review article, several aspects of potential relationships between hiv infection and cardiomyopathy development have been...

Drug abuse is a major comorbidity of HIV infection and cognitive disorders are often more severe in the drug abusing HIV infected population. CD14+CD16+ monocytes, a mature subpopulation of peripheral blood monocytes, are key mediators of HIV neuropathogenesis. Infected CD14+CD16+ monocyte transmigration across the blood brain barrier mediates HIV entry into the brain and establishes a viral re...

Research suggests that HIV-infected individuals who have also been co-infected with HBV face a greater risk of HIV progression. Hepatitis B and infections pose serious public health challenges in sub-Saharan Africa. This study examined the possible co-infection socio-demographic traits attending clinic at referral specialist mission hospital Onitsha, Anambra State, Nigeria. Two hundred twenty (...

Human immunodeficiency virus type 1 (HIV-1) is most notable for its role in directly infecting and killing CD4 T cells the immune system, which can lead to acquisition of Acquired Immunodeficiency Syndrome (AIDS). Currently, there are no cures HIV-1, leaving 37 million people with HIV-1 infections definitive treatment. Researchers working towards developing long-term treatments using CRISPR-Cas...

Phytohemagglutin-stimulated child and adult leukocytes equally supported CCR5-dependent (R5) and CXCR4-dependent (X4) HIV-1 replication. In contrast, when phytohemagglutin-stimulated leukocytes from either healthy or congenitally immunodeficient children were cultured on feeder cells, they well supported R5, but not X4 HIV-1 replication, whereas both viruses equally spread in adult cells mainta...

One mechanism proposed to play a role in T-cell depletion in human immunodeficiency virus (HIV) infection is apoptosis (activation-induced cell death). We assessed whether apoptosis is related to activation of T cells in vivo and its possible triggers. DNA was extracted from peripheral blood mononuclear cells IPBMC) taken from 16 vertically HIV-infected children and 9 HIV-negative children born...