Introduction: Sequential lymphomas involving both classical Hodgkin Lymphoma (cHL) and Primary Mediastinal B-cell have been previously reported but initial diagnosis of cHL followed by a distinct Diffuse Large B-Cell (DLBCL) or vice versa is an extremely rare phenomenon. Multiple etiological factors are involved in lymphoma pathogenesis. The major histocompatibility complex (MHC) has studied ex...

To the Editor: 1 work at an overseas American institution, and there are extended delays in receipt of journals by our medical library. So, it was only a few days ago that I saw the article entitled “Weak Association between HLA-B27 and the Spondylarthropies in Lebanon,” which was published in the February 1997 issue of Arthritis & Rheumatism (1). I would like to draw the attention of the Leban...

Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP. Objective: To investigate the association of HLA class II alleles and haplotypes with BP in Iranian population. Methods: Fifty pa...

Background: In addition to Human Leukocyte Antigens (HLA) compatibility, gene polymorphisms in cytokines might also be important in the quality of allogeneic immune response. Objective: To evaluate the influence of HLA-DR matching and a number of cytokine gene polymorphisms on acute rejection after living-unrelated donor (LURD) kidney transplantation. Methods: A total of 42 renal transplants pe...

Minor histocompatibility antigens (MiHAs) are polymorphic peptides on the cell surface derived from self-proteins that capable to induce an immune response during allogeneic hematopoietic stem cells transplantation. Their presentation occurs in context of certain major complex (HLA – human leucocyte antigen) alleles. One most common HLA alleles is HLA-A*02:01. Accordingly, for a significant num...

testing revealed that the patient was positive for HLA-DRB1*04, HLA-DRB1*12, HLA-DQB1*03, andHLA-DQB1*04. To best of our knowledge, this is first case fulminant T1DM reported to occurimmediately after COVID-19 infection.

Abstract Activation of CD8 +T cells against pathogens and cancers involves the recognition antigenic peptides presented in complex with human leukocyte antigen (HLA) class-I proteins. Peptide binding to HLA-I proteins is coordinated by a multi-protein called peptide loading (PLC). Tapasin, key PLC component, facilitates optimization peptides. However, different allotypes have variable requireme...

Recently, we have shown that HLA-A*02:01 and HLA-A*24:02 in de novo metastatic prostate cancer (MPCa) an important role disease progression. Since MPCa represents a small group among patients diagnosed with (PCa), it was obvious to try extend the validity of our results larger cohorts PCa patients. Herein, analyzed irrespective their status at diagnosis include, besides MPCa, those localized (L...