The literature review presents the characteristics of human leukocyte antigen (HLA)-B27 as a factor contributing to development psoriatic arthritis. HLA-B27 is class I surface encoded by major histocompatibility complex (MHC) B locus located on chromosome 6. main function present antigenic peptides CD8+ T-cells. most important genetic biomarker for arthritis, it provides phenotypic differentiat...

Background: It has been arguedthat unprecedented degree of human leukocyte antigen (HLA) loci polymorphism within a population is requiredto avoid the devastating effects of infectious diseases. The present study was conducted to determine the associations between some of HLA classI genes and the outcome of hepatitis B virus (HBV) infection. Methods: Using sequential sampling method, 64 individ...

Virus-specific CD8+ T cell responses play an important role in the natural course of infection; however, the impact of certain CD8+ T cell responses in determining clinical outcome has not been fully defined. A well-defined cohort of women inoculated with HCV from a single source showed that HLA-B27 has a strong association with spontaneous clearance. The immunological basis for this associatio...

Psoriatic arthritis is a chronic destructive joint disease. About 40% of psoriatic arthritis patients are positive for human lymphocyte antigens (HLA)-B27. This study investigated the relationship between HLA-B27 and clinical manifestations and prognosis in psoriatic arthritis patients. Demographic, clinical, and laboratory data were analyzed from 41 psoriatic arthritis patients with regular fo...

Objective: To find out the prevalence of Human Leucocyte Antigen B27 (HLA-B27) in inflammatory bowel disease patients in Jordan. Methods: Over the last year (2005) all inflammatory bowel disease (IBD) patients attending the gastroenterology outpatient clinic at King Hussein Medical Center(KHMC), were given a questionnaire asking them to report back pain and the characteristics of this pain. The...

background: hla-b*27 is strongly associated with ankylosing spondylitis (as). it represents a family of alleles that differ among ethnic groups. objective: the aim of this study was to determine the distribution of hla-b*27 alleles in as patients and healthy controls in isfahan (iran). methods: sixty as patients and 430 healthy blood donors were selected. all subjects were hla-b*27 positive by ...

We describe the use of flow cytofluorometry to type lymphocytes for HLA-B27 antigens. We modified the cytotoxicity test of Terasaki and McClelland [Nature (London) 1964;204:998] for use with a flow cytofluorometer. In a second assay we used a commercially available monoclonal anti-HLA-B27 antibody and indirect immunofluorescence staining of cell surfaces. Although this antibody cross reacts wit...

Recombinant human interleukin (rhIL)-11 has anti-inflammatory and protective effects in models of intestinal mucosal injury. Our aim was to investigate whether oral treatment with rhIL-11 reverses functional abnormalities in intestinal muscle contractility resulting from human leukocyte antigen (HLA)-B27-dependent gut inflammation. Isometric contractions were studied in jejunal and colonic long...

The peptide binding site of HLA-B27 and other class I Ag consists of a series of pockets that bind peptide side chains. Two of these pockets interact with the amino-terminal peptide residue (pocket A) and with the highly conserved second residue (pocket B). In this study, the role of pockets A and B in HLA-B27-specific T cell allorecognition has been analyzed. Four HLA-B27 mutants with single o...

We report on the development of a method for repeated monitoring of mucosal permeability that allows assessment of the severity of colitis and evaluation of treatment efficacy in HLA-B27 transgenic rats. We determined the extent to which intestinal permeability related to stool condition, colon weight, and histological pathology in precolitic and diseased rats up to 29 weeks old. Intestinal per...