Oxidative stress is a key feature of the atherothrombotic process involved in the etiology of heart attacks, ischemic strokes, and peripheral arterial disease. It stands to reason that antioxidants represent a credible therapeutic option to prevent disease progression and thereby improve outcome, but despite positive findings from in vitro studies, clinical trials have failed to consistently sh...

A stem cell is an undifferentiated cell in the body with undetermined function capable of forming various tissues under definite signals received from the body. Stem cell research in animals using embryonal stem cells has been an ongoing program in the west with fruitful results. However, only limited information is available with the use of stem cells in human beings. Of the various sources of...

Introduction The management of base of tongue carcinoma continue to be a major challenge in head and neck oncology. Our aim in this prospective study was to evaluate the outcome following ultrasound-guided interstitial photodynamic therapy (US-iPDT) of stage IV tongue base carcinoma. Patients’ reports on quality of life with clinical and radiological evaluation were the main end point parameter...

The loss of expression of particular microRNAs can contribute to tumorigenesis. Kota et al. (2009) now explore in a mouse model a promising new approach for the treatment of liver cancer-re-establishing the expression of an miRNA using a viral vector.

Nearly 36 million people live with the human immunodeficiency virus (HIV). Despite incredible advances in combined antiretroviral therapy, the hopes for a definitive cure and an effective vaccine have been frustrated by the seemingly endless capacity of the virus to subvert the host defenses, to persist in a latent state, and to resist drug interventions. Recent work, however, sheds new light o...

The identification of numerous breast cancer antigens has generated increasing enthusiasm for the application of immune-based therapies in breast malignancies. Although the use of monoclonal antibodies has revolutionized the "targeted therapy" of breast cancer, and the immunomodulatory effects of bisphosphonates continue to be evaluated, few studies to date have demonstrated widespread utility ...

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of extracellular amyloid-beta peptide (Aβ) and intracellular neurofibrillar tangles, associated with loss of neurons in the brain and consequent learning and memory deficits. Aβ is the major component of the senile plaques and is believed to play a central role in the development and progress of AD both in ...

© The Author 2013. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/ . ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 1 Stem cell therapy for Alzheimer’...

Major new approvals of drugs for cancer in the last few years have been in the immuno-oncology field where the body’s own defense systems have been empowered to combat cancer [1]. Drugs which target the immune check-point protein like Keytruda, Opdivo, Yervoy, Bavencio and others have been launched into the market based on their unique treatment paradigms. Other immunotherapies which are also b...