Cross-sectional analyses have demonstrated an association between use of hormonal contraceptives and shedding of herpes simplex virus (HSV). This prospective study evaluated the effect of initiating use of hormonal contraception on cervical HSV detection. Two hundred women who were seropositive for HSV-2 and human immunodeficiency virus (HIV) type 1 were examined for cervical mucosal HSV by use...

Hormonal therapy has been playing an important role in the treatment of prostate cancer. However, it has recently been the subject of criticism that it shows minimal effectiveness, it may reduce patients' quality of life, and induce adverse effects. On the other hand, next-generation hormonal drugs have provided new strategies for hormonal therapy to overcome advanced prostate cancer. Therefore...

In a variety of cell types extracellular hormonal stimuli varying in time are transfered across the cell membrane into repetitive spikes of the intracellular calcium concentration ([Ca2+]i). Distinct temporal patterns of [Ca2+]i spikes are capable of regulating the function and structure of target cells. Here, we investigate the ability of transmembrane signaling to encode time-varying hormonal...

Long relegated to the backwaters of neuroendocrinology, it is becoming increasingly apparent that glial cells of the central and peripheral nervous system are key participants because they are capable of both sending and receiving hormonal signals. Hormones are also a critical component of neuronal/glial cross talk, leading to neuromodulatory and neurotrophic actions under physiological and pat...

pigment epithelium-derived factor (pedf) is a glycoprotein that belongs to the family of non-inhibitory serpins. the broad spectrum of pedf biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and anti-metastatic properties. although the structural domains of the pedf gene that mediate such diverse ef...