A two part study utilizing isotactic poly(4 -methyl-1-pentene) (PMP) was undertaken to investigate a three stage process (melt-extrusion/annealing/uniaxial-stretching) (MEAUS) to produce microporous films. In this report, the thermal annealing (second stage) and subsequent uniaxial-stretching (third stage) results of selected PMP films from three resins, labeled A, B & C, are discussed. From se...

in this research, mechanical alloying was used to synthesize ultrafine grained aa2024 and aa2024-b4c powders in an attrition mill under argon atmosphere up to 50 h with the rotational speed of 400 rpm. in order to determine the grain size of the matrix, x-ray diffraction test and williamson–hall method was used. after mechanical alloying, hot pressing and hot extrusion were used for densificati...

The aim of the work reported herein was to implement process analytical technology (PAT) tools during hot melt extrusion (HME) in order to obtain a better understanding of the relationship between HME processing parameters and the extruded formulations. For the first time two in-line NIR probes (transmission and reflectance) have been coupled with HME to monitor the extrusion of the water insol...

Nano-sized TiCx/2009Al composites (with 5, 7, and 9 vol% TiCx) were fabricated via the combustion synthesis of the 2009Al-Ti-CNTs system combined with vacuum hot pressing followed by hot extrusion. In the present study, CNTs were used as the carbon source to synthesize nano-sized TiCx particles. An attempt was made to correlate the effect of ground CNTs by milling and the distribution of synthe...

Currently, the pharmaceutical and healthcare industries are moving through a period of unparalleled change. Major multinational pharmaceutical companies are restructuring, consolidating, merging and more importantly critically assessing their competitiveness to ensure constant growth in an ever-more demanding market where the cost of developing novel products is continuously increasing. The pha...

While preparing the composite preform in the powder metallurgy Lab, the various defects due to porosity, open crack and residual stresses are possible. This may lead to poor life and strength of materials. It is difficult to predict the defects in the form of pores physically in the powder metallurgy Lab. To simplify this kind of problem, the Scanning Electron Microscope (SEM) images are genera...

In this study, we examine the relationship between the physical structure and dissolution behavior of olanzapine (OLZ) prepared via hot-melt extrusion in three polymers [polyvinylpyrrolidone (PVP) K30, polyvinylpyrrolidone-co-vinyl acetate (PVPVA) 6:4, and Soluplus® (SLP)]. In particular, we examine whether full amorphicity is necessary to achieve a favorable dissolution profile. Drug–polymer m...

The hot deformation behavior and microstructural evolution of Ti-44Al-5V-1Cr alloy were investigated by hot compression tests at temperatures of 1000–1250 ◦C and strain rates of 0.001–1 s−1. It was indicated that the dependence of peak stress on deformation temperature and strain rate could be accurately described by a hyperbolic sine type equation. The activation energy, Q, was estimated to be...

In the past two decades, the repair and reconstruction of musculoskeletal tissues using biodegradable scaffold materials has emerged as one of the most promising approaches in tissue engineering. The aim of this study is to process, via hot melt extrusion, the biodegradable and biocompatible polymeric materials; poly(ethylene oxide) (PEO), poly(ethylene glycol) (PEG), ⍺lactose monohydrate and p...