S trike a bell or a drum and its sound will be dominated by a few vibrational patterns (“modes”), each of which has a characteristic shape, frequency, and damping rate. A new study has found that the mechanical response of the human brain to impact can similarly be described with a small number of dynamic modes. Kaveh Laksari of the University of Arizona in Tucson, Mehmet Kurt of the Stevens In...

Arginine kinase provides a model for functional dynamics, studied through crystallography, enzymology, and nuclear magnetic resonance. Structures are now solved, at ambient temperature, for the transition state analog (TSA) complex. Analysis of quasi-rigid sub-domain displacements show that differences between the two TSA structures average about 5% of changes between substrate-free and TSA for...

A label-free and sensitive faradic impedance spectroscopy (FIS) aptasensor based on target-induced aptamer displacement was developed for the determination of lysozyme as a model system. The aptasensor was fabricated by self-assembling the partial complementary single strand DNA (pcDNA)-lysozyme binding aptamer (LBA) duplex on the surface of a gold electrode. To measure lysozyme, the change in ...

Measuring deformation of vibrating specimens whose dimensions are in the submillimeter range introduces a number of difficulties using laser interferometry. Normal interferometry is not suitable because of a phase ambiguity problem. In addition, the noise effect is much more serious in the measurement of small objects because a high-magnification lens is used. We present a method for full-field...

A displacement-sensitive capacitive probe technique was used in the first turn of guinea pig cochleas to examine whether the motion of the basilar membrane includes a displacement component analogous to the dc receptor potentials of the hair cells. Such a "dc" component apparently exists. At a given location on the basilar membrane, its direction toward scala vestibuli (SV) or scala tympani (ST...

Stochastic processes in the form of the classical Brownian motion or internal phonon fluctuations may be studied by the use of a microcantilever. We present certain dynamic aspects of the behavior of the noise and the delayed fluctuations exhibited by a microcantilever. In particular, we present an analytic solution describing the transient response of the oscillator and discuss how self-excita...

PURPOSE Recent clinical trials and animal studies have indicated that the tissue sensitivity to radiation induced lung injury (RILI) may be region- specific. In this study, we propose a new 4D cone beam CT (CBCT) basedcompliance imaging method to measure regional pulmonary function change in precisely irradiated small animal under CBCT guidance on small animal radiation research platform (SARRP...

The protostar B335 was observed in the 1.3 mm continuum and in the H2CO 312 → 211 line with an angular resolution of about 8. The mass of the inner envelope detected by the dust continuum emission is about 0.02 M⊙. The H2CO spectrum at the protostellar position shows a blue-skewed double peak profile, suggesting that the kinematics of the inner envelope is dominated by infall motion. When the b...