This article describes the judgements used to interpret evidence in evidence-based medicine (EBM) and health technology assessment (HTA). It outlines the methods and processes of EBM and HTA. Respectively, EBM and HTA are approaches to medical clinical decision making and efficient allocation of scarce health resources. At the heart of both is a concern to review and synthesise evidence, especi...

BACKGROUND Decision-analytic modelling (DAM) has become a widespread method in health technology assessments (HTA), but the extent to which modelling is used differs among international HTA institutions. In Germany, the use of DAM is optional within HTAs of the German Institute of Medical Documentation and Information (DIMDI). Our study examines the use of DAM in DIMDI HTA reports and its effec...

Microbial amino acid biosynthesis is a proven yet underexploited target of antibiotics. The biosynthesis of methionine in particular has been shown to be susceptible to small-molecule inhibition in fungi. The first committed step in Met biosynthesis is the acylation of homoserine (Hse) by the enzyme homoserine transacetylase (HTA). We have identified the MET2 gene of Cryptococcus neoformans H99...

Introduction The use of Health Technology Assessment (HTA) in hospitals contributes to decision-making, professional training, greater interaction with technical scientific knowledge, resource-saving, and partnerships. Hospitals are strategic for the field clinical management quality care open partnerships national international agencies groups. Despite hospital-based (HB)-HTA movement, incipie...

OBJECTIVES The purpose of this project was to evaluate local decision support tools used in the Danish hospital sector from a theoretical and an empirical point of view. METHODS The use of local decision support was evaluated through questionnaires sent to all county health directors, all hospital managers, and all heads of clinical departments in cardiology, orthopedic surgery, and intensive...

OBJECTIVES The aim of this study was to describe the history and present situation with health technology assessment (HTA) in Israel. METHODS The method used in this study was a historical analysis based mainly on the knowledge of the authors, but supplemented by the published literature. RESULTS HTA originated in Israel as a centralized function conducted under the auspice of research, dev...

Solving linear systems is an important problem for scientific computing. Exploiting parallelism is essential for solving complex systems, and this traditionally involves writing parallel algorithms on top of a library such as MPI. The SPIKE family of algorithms is one well-known example of a parallel solver for linear systems. The Hierarchically Tiled Array data type extends traditional data-pa...

background: health technology assessment (hta) is a tool utilized for efficient dissemination of technology. for the purpose of encouraging decision-makers to utilize this tool, at first, we need to identify the obstacles in the processes of preparation, utilization, and implementation of htas. this study aims to define these barriers and offer solutions for effective utilization of hta reports...

OBJECTIVES To describe and explore the reasons for the current health technology assessment (HTA) landscape in the United States. METHODS Relying on multiple historical literature and other documents as well as drawing on personal experiences and observations, we describe, evaluate, and explain the evolving and dynamic HTA-related evidence landscape. RESULTS The present HTA-related landscap...

The Arabidopsis thaliana histone H2A gene HTA1 is essential for efficient transformation of Arabidopsis roots by Agrobacterium tumefaciens. Disruption of this gene in the rat5 mutant results in decreased transformation. In Arabidopsis, histone H2A proteins are encoded by a 13-member gene family. RNA encoded by these genes accumulates to differing levels in roots and whole plants; HTA1 transcrip...